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MERS-CoV in Arabian camels in Africa and Central Asia

Chu Daniel K.W., Chan Samuel M.S., Perera Ranawaka A.P.M., Miguel Eve, Roger François, Chevalier Véronique, Poon Leo L.M., Peiris Malik. 2017. MERS-CoV in Arabian camels in Africa and Central Asia. Virus Evolution, 3 (1), suppl. : S16-S17. International BioInformatics Workshop on Virus Evolution and Molecular Epidemiology. 21, Séoul, Corée du Sud, 14 August 2016/19 August 2016.

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Abstract : Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causing infections in humans is genetically indistinguishable from the virus found in Arabian camels (dromedaries) in the Middle East. Although no primary human case of MERS was reported outside the Arabian Peninsula, camel populations in Africa are known to have high prevalence of antibodies against MERS-CoV. We carried out surveillance for MERS-CoV in dromedaries in Africa and Central Asia. By MERS-CoV spike pseudoparticle neutralization assay we confirmed that camel serum samples from African countries have high prevalence of MERS-CoV antibodies. Using RT-qPCR we detected MERS-CoV positives in camel nasal swabs from all different African countries from which samples were collected. However, dromedary serum and swab samples from Kazakhstan in Central Asia were negative for MERS-CoV by these assays. Phylogenetic analysis of the spike gene revealed that MERS-CoVs from Africa formed a cluster closely related to but distinct from the viruses from the Arabian Peninsula. Results from this study suggest that MERS-CoV is actively circulating in dromedary populations in Africa and the virus in Africa is phylogenetically distinct from that in the Middle East. (Résumé d'auteur)

Mots-clés Agrovoc : Coronavirinae, Dromadaire, Genre humain, Surveillance épidémiologique, Génétique des populations, Phylogénie, Distribution géographique, zoonose, Maladie de l'homme, Transmission des maladies

Mots-clés géographiques Agrovoc : Afrique, Asie centrale

Mots-clés libres : MERS-CoV, Camel, Africa, Asia

Classification Agris : L73 - Animal diseases
000 - Other themes

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

  • Chu Daniel K.W., University of Hong Kong (CHN)
  • Chan Samuel M.S., University of Hong Kong (CHN)
  • Perera Ranawaka A.P.M., University of Hong Kong (CHN)
  • Miguel Eve
  • Roger François, CIRAD-BIOS-UMR ASTRE (THA) ORCID: 0000-0002-1573-6833
  • Chevalier Véronique, CIRAD-BIOS-UMR ASTRE (KHM)
  • Poon Leo L.M., University of Hong Kong (CHN)
  • Peiris Malik, University of Hong Kong (CHN)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/585241/)

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