A serological survey of anthrax in domestic dogs in Zimbabwe: A potential tool for anthrax surveillance

Mukarati Norman L., Ndumnego Okechukwu C., Van Heerden Henriette, Matope Gift, Caron Alexandre, De Garine-Wichatitsky Michel, Pfukenyi Davies Mubika. 2018. A serological survey of anthrax in domestic dogs in Zimbabwe: A potential tool for anthrax surveillance. Epidemiology and Infection, 146 (12) : pp. 1526-1532.

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Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Abstract : Anthrax is an important disease caused by the bacterium Bacillus anthracis affecting both domestic and wild animals at the wildlife/livestock interface, defined here as a physical space in which wild and domestic species overlap in range and potentially interact. In endemic regions, sporadic anthrax outbreaks occur, causing significant deaths of both wildlife and livestock and sporadically, humans. However, it may also occur as isolated outbreaks with a few animals affected. Such isolated anthrax outbreaks maybe missed. High seroprevalence among carnivores suggests either regular non-fatal exposure to the pathogen circulating in a given environment, or contact with missed cases through consumption of anthrax carcases. To investigate the relevance of this potential indicator, a cross-sectional study was conducted to determine anthrax seroprevalence in domestic dogs (Canis lupus familiaris) from selected interface and non-interface areas of Zimbabwe with known history of anthrax outbreaks. Based on past anthrax outbreaks in the respective areas, the sites were further classified as high or low risk areas for anthrax outbreaks. Sera were collected from domestic dogs (n = 186) and tested for antibodies against B. anthracis protective antigens (PA) using an ELISA test. The overall seroprevalence was 51.6% (96/186; 95% CI 44.2–59.0). Sites from the non-interface areas recorded a significantly (P < 0.001) higher (72.1%) anthrax seroprevalence compared with those from the wildlife –livestock interface (41.5%). The results demonstrated a strong association (χ2 = 14.3; OR = 3.2, 1.6 < OR < 6.2, P < 0.001) between anthrax seropositivity and interface type. Low-risk sites (42.5%) had a significantly (P = 0.044) lower seroprevalence compared with high-risk sites (58.5%) but still demonstrated high seroprevalence for areas where anthrax was last reported more than 20 years back. Dogs from Tsholotsho South were more than 90-times (OR = 96.5, 13.5 < OR < 690.8) more likely to be seropositive compared with those from Hwange. The study demonstrated the potential to use domestic dogs as indicators of anthrax in the study areas to survey anthrax circulation in supposed low-risk areas and calls for a redefinition of both low and high risk areas for anthrax in Zimbabwe based on an improved surveillance.

Mots-clés géographiques Agrovoc : Zimbabwe

Mots-clés libres : Anthrax, Domestic dogs, Seroprevalence, Wildlife-livestock interface, Zimbabwe

Classification Agris : L73 - Animal diseases

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

  • Mukarati Norman L., University of Zimbabwe (ZWE)
  • Ndumnego Okechukwu C., University of Pretoria (ZAF) - auteur correspondant
  • Van Heerden Henriette, University of Veterinary Science (ZWE)
  • Matope Gift, University of Zimbabwe (ZWE)
  • Caron Alexandre, CIRAD-BIOS-UMR ASTRE (MOZ) ORCID: 0000-0002-5213-3273
  • De Garine-Wichatitsky Michel, CIRAD-BIOS-UMR ASTRE (THA) ORCID: 0000-0002-5438-1473
  • Pfukenyi Davies Mubika, University of Zimbabwe (ZWE)

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