Evolutionary journey of the retroviral restriction gene Fv1

Young George R., Yap Melvyn W., Michaux Johan, Steppan Scott J., Stoye Jonathan P.. 2018. Evolutionary journey of the retroviral restriction gene Fv1. Proceedings of the National Academy of Sciences of the United States of America, 115 (40) : 10130-10135.

Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/nuccore/MH001948 / Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/nuccore/MH727610

Quartile : Outlier, Sujet : MULTIDISCIPLINARY SCIENCES

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Economie-gestion; Psychologie-éthologie-ergonomie

Note générale : Jeu de données enregistrés dans la base GenBank du numéro d'accès MH001948 au MH001969 et MH727610 au MH72761.

Résumé : Both exogenous and endogenous retroviruses have long been studied in mice, and some of the earliest mouse studies focused on the heritability of genetic factors influencing permissivity and resistance to infection. The prototypic retroviral restriction factor, Fv1, is now understood to exhibit a degree of control across multiple retroviral genera and is highly diverse within Mus. To better understand the age and evolutionary history of Fv1, a comprehensive survey of the Muroidea was conducted, allowing the progenitor integration to be dated to ∼45 million years. Intact coding potential is visible beyond Mus, and sequence analysis reveals strong signatures of positive selection also within field mice, Apodemus. Fv1's survival for such a period implies a recurring and shifting retroviral burden imparting the necessary selective pressures—an influence likely also common to analogous factors. Regions of Fv1 adapt cooperatively, highlighting its preference for repeated structures and suggesting that this functionally constrained aspect of the retroviral capsid lattice presents a common target in the evolution of intrinsic immunity.

Mots-clés libres : Restriction factor, Evolution, Host-virus interactions, Retrovirus

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

• Young George R., The Francis Crick Institute (GBR)
• Yap Melvyn W., The Francis Crick Institute (GBR)
• Michaux Johan, CIRAD-BIOS-UMR ASTRE (FRA)
• Steppan Scott J., University of Florida (USA)
• Stoye Jonathan P., The Francis Crick Institute (GBR) - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/589204/)

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