Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resistance in Helicoverpa armigera

Walsh Thomas, Joussen Nicole, Tian Kai, McGaughran Angela, Anderson Craig, Qiu Xinghui, Ahn Seung-Joon, Bird Lisa, Pavlidi Nena, Vontas John, Ryu Jaeeun, Rasool Akhtar, Barony Macedo Isabella, Tay Wee Tek, Zhang Yongjun, Whitehouse Mary E.A., Silvie Pierre, Downes Sharon, Nemec Lori, Heckel David G.. 2018. Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resistance in Helicoverpa armigera. PloS One, 13 (11):e0197760, 19 p.

Journal article ; Article de recherche ; Article de revue à facteur d'impact Revue en libre accès total
Published version - Anglais
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Abstract : The cotton bollworm, Helicoverpa armigera (Hübner) is one of the most serious insect pest species to evolve resistance against many insecticides from different chemical classes. This species has evolved resistance to the pyrethroid insecticides across its native range and is becoming a truly global pest after establishing in South America and having been recently recorded in North America. A chimeric cytochrome P450 gene, CYP337B3, has been identified as a resistance mechanism for resistance to fenvalerate and cypermethrin. Here we show that this resistance mechanism is common around the world with at least eight different alleles. It is present in South America and has probably introgressed into its closely related native sibling species, Helicoverpa zea. The different alleles of CYP337B3 are likely to have arisen independently in different geographic locations from selection on existing diversity. The alleles found in Brazil are those most commonly found in Asia, suggesting a potential origin for the incursion of H. armigera into the Americas.

Mots-clés Agrovoc : Gossypium, Helicoverpa armigera, Résistance aux insecticides, Pyréthrine de syntèse, Espèce envahissante, Allèle, Cytochrome, Recombinaison

Mots-clés géographiques Agrovoc : Brésil

Mots-clés libres : Recombinaison multiple, Cytochrome P450, Cotonnier, Noctuelle, Espèce invasive, Brésil, Allèles de résistance

Classification Agris : H10 - Pests of plants

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

  • Walsh Thomas, CSIRO (AUS)
  • Joussen Nicole, MPIZ (DEU)
  • Tian Kai, CAAS (CHN)
  • McGaughran Angela, CSIRO (AUS)
  • Anderson Craig, CSIRO (AUS)
  • Qiu Xinghui, CAAS (CHN)
  • Ahn Seung-Joon, National Institute of Horticultur al and Herbal Science (KOR)
  • Bird Lisa, Tamwo rth Agricultural Institute (AUS)
  • Pavlidi Nena, Université de Crète (GRC)
  • Vontas John, Université de Crète (GRC)
  • Ryu Jaeeun, CSIRO (AUS)
  • Rasool Akhtar, National Institute for Biotechnology and Genetic Engineering (PAK)
  • Barony Macedo Isabella, UFMG (BRA)
  • Tay Wee Tek, CSIRO (AUS)
  • Zhang Yongjun, CAAS (CHN)
  • Whitehouse Mary E.A., Australian Cotton Research Institute (AUS)
  • Silvie Pierre, CIRAD-PERSYST-UPR AIDA (FRA) ORCID: 0000-0002-3406-6230
  • Downes Sharon, Australian Cotton Research Institute (AUS)
  • Nemec Lori, Australian Cotton Research Institute (AUS)
  • Heckel David G., MPIZ (DEU) - auteur correspondant

Source : Cirad-Agritrop (

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