A multicellular way of life for a multipartite virus

Sicard Anne, Pirolles Elodie, Gallet Romain, Vernerey Marie-Stéphanie, Yvon Michel, Urbino Cica, Peterschmitt Michel, Gutierrez Serafin, Michalakis Yannis, Blanc Stéphane. 2019. A multicellular way of life for a multipartite virus. eLife, 8:e43599, 14 p.

https://doi.org/10.7554/eLife.43599

Article de revue ; Article de recherche ; Article de revue à facteur d'impact

Prévisualisation

Version publiée - Anglais
Utilisation soumise à autorisation de l'auteur ou du Cirad.
Sicard19_Nanovirus_Elife.pdf
Télécharger (1MB) | Prévisualisation

Quartile : Outlier, Sujet : BIOLOGY

Résumé : Multipartite viruses have a segmented genome where each segment is encapsidated separately. In this situation the viral genome is not recapitulated in a single virus particle but in the viral population. How multipartite viruses manage to efficiently infect individual cells with all segments, thus with the whole genome information, is a long-standing but perhaps deceptive mystery. By localizing and quantifying the genome segments of a nanovirus in host plant tissues we show that they rarely co-occur within individual cells. We further demonstrate that distinct segments accumulate independently in different cells and that the viral system is functional through complementation across cells. Our observation deviates from the classical conceptual framework in virology and opens an alternative possibility (at least for nanoviruses) where the infection can operate at a level above the individual cell level, defining a viral multicellular way of life.

Mots-clés Agrovoc : virologie, virus des végétaux, génome, cellule

Classification Agris : H20 - Maladies des plantes

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Auteurs et affiliations