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Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: Insights from a modeling study

Colombi Davide, Serra-Cobo Jordi, Metras Raphaëlle, Apolloni Andrea, Poletto Chiara, López-Roig Marc, Bourhy Hervé, Colizza Vittoria. 2019. Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: Insights from a modeling study. Scientific Reports, 9:537

Journal article ; Article de recherche ; Article de revue à facteur d'impact Revue en libre accès total
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Quartile : Q1, Sujet : MULTIDISCIPLINARY SCIENCES

Abstract : Bats are natural reservoirs of the largest proportion of viral zoonoses among mammals, thus understanding the conditions for pathogen persistence in bats is essential to reduce human risk. Focusing on the European Bat Lyssavirus subtype 1 (EBLV-1), causing rabies disease, we develop a data-driven spatially explicit metapopulation model to investigate EBLV-1 persistence in Myotis myotis and Miniopterus schreibersii bat species in Catalonia. We find that persistence relies on host spatial structure through the migratory nature of M. schreibersii, on cross-species mixing with M. myotis, and on survival of infected animals followed by temporary immunity. The virus would not persist in the single colony of M. myotis. Our study provides for the first time epidemiological estimates for EBLV-1 progression in M. schreibersii. Our approach can be readily adapted to other zoonoses of public health concern where long-range migration and habitat sharing may play an important role.

Mots-clés Agrovoc : Chiroptera

Mots-clés géographiques Agrovoc : Europe

Classification Agris : L73 - Animal diseases

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Auteurs et affiliations

  • Colombi Davide, University of Turin (ITA)
  • Serra-Cobo Jordi, University of Barcelona (ESP)
  • Metras Raphaëlle, CIRAD-BIOS-UMR ASTRE (FRA)
  • Apolloni Andrea, CIRAD-BIOS-UMR ASTRE (SEN)
  • Poletto Chiara, INSERM (FRA)
  • López-Roig Marc, University of Barcelona (ESP)
  • Bourhy Hervé, Institut Pasteur (FRA)
  • Colizza Vittoria, INSERM (FRA) - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/591721/)

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