Can genotype mismatch really affect the level of protection conferred by Newcastle disease vaccines against heterologous virulent strains?

Liu Haijin, Servan de Almeida Renata, Gil Patricia, Majó Natàlia, Nofrarías Miquel, Briand François-Xavier, Jestin Véronique, Albina Emmanuel. 2018. Can genotype mismatch really affect the level of protection conferred by Newcastle disease vaccines against heterologous virulent strains?. Vaccine, 36 (27) : 3917-3925.

https://doi.org/10.1016/j.vaccine.2018.05.074

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Quartile : Q2, Sujet : MEDICINE, RESEARCH & EXPERIMENTAL / Quartile : Q2, Sujet : IMMUNOLOGY

Résumé : Newcastle disease (ND), caused by virulent class II avian paramyxovirus 1 (Newcastle disease virus, NDV), occurs sporadically in poultry despite their having been immunized with commercial vaccines. These vaccines were all derived from NDV strains isolated around 70 years ago. Since then, class II NDV strains have evolved into 18 genotypes. Whether the vaccination failure results from genotype mismatches between the currently used vaccine strains and field-circulating velogenic strains or from an impaired immune response in the vaccination remains unclear. To test the first hypothesis, we performed a heterologous genotype II vaccine/genotype XI challenge in one-day old specific pathogen free (SPF) chicks and reproduced viral shedding. We then produced two attenuated strains of genotype II and XI by reverse genetics and used them to immunize two-week old SPF chickens that were subsequently challenged with velogenic strains of genotypes II, VII and XI. We found that both vaccines could induce antibodies with hemagglutination inhibition titers higher than 6.5 log2. Vaccination also completely prevented disease, viral shedding in swabs, and blocked viral replication in tissues from different genotypes in contrast to unvaccinated chickens that died shortly after challenge. Taken together, our results support the hypothesis that, in immunocompetent poultry, genotype mismatch is not the main reason for vaccination failure.

Mots-clés Agrovoc : maladie de Newcastle, volaille, vaccin

Mots-clés géographiques Agrovoc : France, Madagascar

Mots-clés libres : Newcastle disease, Genotype mismatch, Protection, Vaccine, Viral shedding

Classification Agris : L73 - Maladies des animaux
S50 - Santé humaine

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

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