Tracing cross species transmission of Mycobacterium bovis at the wildlife/livestock interface in South Africa

Sichewo Petronillah Rudo, Hlokwe Tiny, Etter Eric, Michel Anita Luise. 2020. Tracing cross species transmission of Mycobacterium bovis at the wildlife/livestock interface in South Africa. BMC Microbiology, 20:49, 9 p.

Journal article ; Article de recherche ; Article de revue à facteur d'impact Revue en libre accès total
Published version - Anglais
License Licence Creative Commons.
Sichewo 20 TracingCrossSpTransmMbWL-LivestInterfaceSA.pdf

Télécharger (791kB) | Preview

Abstract : Background: Bovine tuberculosis (bTB) affects cattle and wildlife in South Africa with the African buffalo (Syncerus caffer) as the principal maintenance host. The presence of a wildlife maintenance host at the wildlife/livestock interface acting as spill-over host makes it much more challenging to control and eradicate bTB in cattle. Spoligotyping and mycobacterial interspersed repetitive unit-variable number of tandem repeat (MIRU-VNTR) genotyping methods were performed to investigate the genetic diversity of Mycobacterium bovis (M. bovis) isolates from cattle and wildlife, their distribution and transmission at the wildlife/livestock interface in northern Kwa-Zulu Natal (KZN), South Africa. Results: SB0130 was identified as the dominant spoligotype pattern at this wildlife/livestock interface, while VNTR typing revealed a total of 29 VNTR profiles (strains) in the KZN province signifying high genetic variability. The detection of 5 VNTR profiles shared between cattle and buffalo suggests M. bovis transmission between species. MIRU-VNTR confirmed co-infection in one cow with three strains of M. bovis that differed at a single locus, with 2 being shared with buffalo, implying pathogen introduction from most probably unrelated wildlife sources. Conclusion: Our findings highlight inter and intra species transmission of bTB at the wildlife/livestock interface and the need for the implementation of adequate bTB control measures to mitigate the spread of the pathogen responsible for economic losses and a public health threat.

Mots-clés Agrovoc : Mycobacterium bovis, Syncerus caffer, Tuberculose, Transmission des maladies, Contrôle de maladies, Bétail, Animal sauvage

Mots-clés géographiques Agrovoc : Afrique du Sud

Mots-clés complémentaires : Tuberculose bovine

Mots-clés libres : African buffalo, Mycobacterium bovis (M. bovis), Bovine tuberculosis, Cattle, Strains, Wildlife, Wildlife-livestock interface

Classification Agris : L73 - Animal diseases

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Auteurs et affiliations

  • Sichewo Petronillah Rudo, University of Pretoria (ZAF) - auteur correspondant
  • Hlokwe Tiny, ARC (AUS)
  • Michel Anita Luise, University of Pretoria (ZAF)

Source : Cirad-Agritrop (

View Item (staff only) View Item (staff only)

[ Page générée et mise en cache le 2021-04-15 ]