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Impact of a 3-year mass drug administration pilot project for taeniasis control in Madagascar

Ramiandrasoa Noromanana Sylvia, Ravoniarimbinina Pascaline, Rafalimanantsoa Solofoniaina Armand, Andrianjafy Rakotomanga Iharilanto Patricia, Hermas Andrianarisoa Samuel, Molia Sophie, Labouche Anne-Marie, Fahrion Anna Sophie, Donadeu Meritxell, Abela-Ridder Bernadette, Rajaonatahina Davidra. 2020. Impact of a 3-year mass drug administration pilot project for taeniasis control in Madagascar. PLoS Neglected Tropical Diseases, 14 (9):e0008653, 13 p.

Journal article ; Article de recherche ; Article de revue à facteur d'impact Revue en libre accès total
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Abstract : Taenia solium is endemic in Madagascar and presents a significant burden on the population and the health system. The parasite cycles through humans who host the adult tapeworm, and pigs that host the larval stages. Accidental infection of humans may occur with the larval stages which encyst in the nervous central system causing neurocysticercosis, a major cause of seizure disorders and a public health problem. One of the interventions to facilitate the control of the disease is mass drug administration (MDA) of the human population with taeniacide. Here we describe a pilot project conducted in Antanifotsy district of Madagascar from 2015 to 2017 where three annual rounds of MDA (praziquantel, 10mg/Kg) were undertaken in 52 villages. Changes in the prevalence of taeniasis were assessed before, during and after the treatments. A total of 221,308 treatments were given to all eligible people above 5 years of age representing a 95% coverage of the targeted population. No major adverse effects were notified related to the implementation of the MDA. The prevalence of taeniasis was measured using Kato-Katz and copro-antigen techniques. Analyses undertaken combining the results of the Kato-Katz with copro-antigen, or using the Kato-Katz results alone, showed that there was a significant reduction in taeniasis 4 months after the last MDA, but 12 months later (16 months after the last MDA) the taeniasis prevalence had returned to its original levels. Results of the pilot project emphasize the need of a multi-sectorial One-Health approach for the sustained control of T. solium.

Mots-clés Agrovoc : Taenia solium, Cysticercose, Thérapeutique médicamenteuse, Enquête pathologique, conseil, Porcin, observation

Mots-clés géographiques Agrovoc : Madagascar

Mots-clés complémentaires : campagne de distribution massive de médicaments, séroprévalence, Recommandation, neurocysticercose

Mots-clés libres : Taeniasis, Cysticercosis, Mass treatment, Madagascar, Swine, Pilot studies, Adverse reactions, Drug administration, Neurocysticercosis

Classification Agris : L73 - Animal diseases
000 - Other themes

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Auteurs et affiliations

  • Ramiandrasoa Noromanana Sylvia, Ministère de la santé publique (Madagascar) (MDG) - auteur correspondant
  • Ravoniarimbinina Pascaline, Ministère de la santé publique (Madagascar) (MDG)
  • Rafalimanantsoa Solofoniaina Armand, Ministère de la santé publique (Madagascar) (MDG)
  • Andrianjafy Rakotomanga Iharilanto Patricia, Ministère de la santé publique (Madagascar) (MDG)
  • Hermas Andrianarisoa Samuel, OMS (MDG)
  • Molia Sophie, CIRAD-BIOS-UMR ASTRE (FRA)
  • Labouche Anne-Marie, OMS (CHE)
  • Fahrion Anna Sophie, FLI (DEU)
  • Donadeu Meritxell, University of Melbourne (AUS) - auteur correspondant
  • Abela-Ridder Bernadette, OMS (CHE)
  • Rajaonatahina Davidra, Centre Hospitalier Universitaire Joseph Ravoahangy Andrianavalona (MDG)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/596547/)

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