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First investigation of pathogenic bacteria, protozoa and viruses in rodents and shrews in context of forest-savannah-urban areas interface in the city of Franceville (Gabon)

Mangombi J.B., N'Dilimabaka Nadine, Lekana-Douki Jean-Bernard, Banga Octavie, Maghendji-Nzondo Sydney, Bourgarel Mathieu, Leroy Eric M., Fenollar Florence, Mediannikov Oleg. 2021. First investigation of pathogenic bacteria, protozoa and viruses in rodents and shrews in context of forest-savannah-urban areas interface in the city of Franceville (Gabon). PloS One, 16 (3):e0248244, 28 p.

Journal article ; Article de recherche ; Article de revue à facteur d'impact Revue en libre accès total
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Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie; Staps

Abstract : Rodents are reservoirs of numerous zoonotic diseases caused by bacteria, protozoans, or viruses. In Gabon, the circulation and maintenance of rodent-borne zoonotic infectious agents are poorly studied and are often limited to one type of pathogen. Among the three existing studies on this topic, two are focused on a zoonotic virus, and the third is focused on rodent Plasmodium. In this study, we searched for a wide range of bacteria, protozoa and viruses in different organs of rodents from the town of Franceville in Gabon. Samples from one hundred and ninety-eight (198) small mammals captured, including two invasive rodent species, five native rodent species and 19 shrews belonging to the Soricidae family, were screened. The investigated pathogens were bacteria from the Rickettsiaceae and Anaplasmataceae families, Mycoplasma spp., Bartonella spp., Borrelia spp., Orientia spp., Occidentia spp., Leptospira spp., Streptobacillus moniliformis, Coxiella burnetii, and Yersinia pestis; parasites from class Kinetoplastida spp. (Leishmania spp., Trypanosoma spp.), Piroplasmidae spp., and Toxoplasma gondii; and viruses from Paramyxoviridae, Hantaviridae, Flaviviridae and Mammarenavirus spp. We identified the following pathogenic bacteria: Anaplasma spp. (8.1%; 16/198), Bartonella spp. (6.6%; 13/198), Coxiella spp. (5.1%; 10/198) and Leptospira spp. (3.5%; 7/198); and protozoans: Piroplasma sp. (1%; 2/198), Toxoplasma gondii (0.5%; 1/198), and Trypanosoma sp. (7%; 14/198). None of the targeted viral genes were detected. These pathogens were found in Gabonese rodents, mainly Lophuromys sp., Lemniscomys striatus and Praomys sp. We also identified new genotypes: Candidatus Bartonella gabonensis and Uncultured Anaplasma spp. This study shows that rodents in Gabon harbor some human pathogenic bacteria and protozoans. It is necessary to determine whether the identified microorganisms are capable of undergoing zoonotic transmission from rodents to humans and if they may be responsible for human cases of febrile disease of unknown etiology in Gabon.

Mots-clés Agrovoc : zoonose, Virus pathogène, Maladie bactérienne, Protozoa, relation homme-faune, Plasmodium, Rongeur, Musaraigne, Anaplasma, Anaplasmataceae

Mots-clés géographiques Agrovoc : Gabon

Mots-clés complémentaires : Rickettsiaceae, Lophuromys, Lemniscomys striatus, Praomys, Candidatus Bartonella gabonensis

Mots-clés libres : Reservoir hosts, Pathogen diversity, Micro-mammifères, Central Africa

Classification Agris : S50 - Human health
L73 - Animal diseases

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Auteurs et affiliations

  • Mangombi J.B., CIRMF (GAB)
  • N'Dilimabaka Nadine, CIRMF (GAB) - auteur correspondant
  • Lekana-Douki Jean-Bernard, CIRMF (GAB)
  • Banga Octavie, CIRMF (GAB)
  • Maghendji-Nzondo Sydney, Université des sciences de la santé (GAB)
  • Bourgarel Mathieu, CIRAD-BIOS-UMR ASTRE (ZWE) ORCID: 0000-0001-9774-7669
  • Leroy Eric M., CIRMF (GAB)
  • Fenollar Florence, Université Aix-Marseille (FRA)
  • Mediannikov Oleg, IRD (SEN)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/597838/)

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