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Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa

Bataille Arnaud, Salami Habib, Seck Ismaïla, Lo Modou Moustapha, Ba Aminata, Diop Mariame, Sall Baba, Faye Coumba, Lo Mbargou, Kaba Lanceï, Sidime Youssouf, Keyra Mohamed, Diallo Alpha Oumar Sily, Niang Mamadou, Sidibé Cheick Abou Kounta, Sery Amadou, Dakouo Martin, El Mamy Ahmed Bezeid, El Arbi Ahmed Salem, Barry Yahya, Isselmou Ekaterina, Habiboullah Habiboullah, Lella Abdellahi Salem, Doumbia Baba, Baba Gueya Mohamed, Coste Caroline, Squarzoni Diaw Cécile, Kwiatek Olivier, Libeau Geneviève, Apolloni Andrea. 2021. Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa. PLoS Pathogens, 17 (3):e1009397, 23 p.

Journal article ; Article de recherche ; Article de revue à facteur d'impact Revue en libre accès total
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Url - jeu de données : https://www.ncbi.nlm.nih.gov/nuccore/MT072445 / Url - jeu de données : https://www.ncbi.nlm.nih.gov/nuccore/MT072545

Abstract : Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Phylogenetic analyses identified the presence of multiple PPRV genetic clades that may be considered as part of different transmission networks evolving in parallel in West Africa. A strong correlation was found between virus genetic distance and network-related distances. Viruses sampled within the same mobility communities are significantly more likely to belong to the same genetic clade. These results provide evidence for the importance of animal mobility in PPR transmission in the region. Some nodes of the network were associated with PPRV sequences belonging to different clades, representing potential “hotspots” for PPR circulation. Our results suggest that combining genetic and mobility network data could help identifying sites that are key for virus entrance and spread in specific areas. Such information could enhance our capacity to develop locally adapted control and surveillance strategies, using among other risk factors, information on animal mobility.

Mots-clés Agrovoc : Transmission des maladies, Migration animale, Peste des petits ruminants, Virus peste petits ruminants, Virus des animaux, Analyse de réseau, Génétique, Phylogénie, Distribution des populations

Mots-clés géographiques Agrovoc : Afrique occidentale, Sénégal, Mauritanie

Mots-clés libres : Genetics, Phylogenetic analysis, Ruminants, Senegal, Network analysis, Algorithms, Genetic linkage, Mauritania

Classification Agris : L73 - Animal diseases
L20 - Animal ecology

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Agence(s) de financement européenne(s) : European Commission

Auteurs et affiliations

  • Bataille Arnaud, CIRAD-BIOS-UMR ASTRE (FRA) - auteur correspondant
  • Salami Habib, LNERV (SEN)
  • Seck Ismaïla, DSV Dakar (SEN)
  • Lo Modou Moustapha, ISRA (SEN)
  • Ba Aminata, ISRA (SEN)
  • Diop Mariame, ISRA (SEN)
  • Sall Baba, DSV Dakar (SEN)
  • Faye Coumba, DSV Dakar (SEN)
  • Lo Mbargou, DSV Dakar (SEN)
  • Kaba Lanceï, Institut Supérieur des Sciences et de Médecine Vétérinaire (GIN)
  • Sidime Youssouf, Institut Supérieur des Sciences et de Médecine Vétérinaire (GIN)
  • Keyra Mohamed, Institut Supérieur des Sciences et de Médecine Vétérinaire (GIN)
  • Diallo Alpha Oumar Sily, Institut Supérieur des Sciences et de Médecine Vétérinaire (GIN)
  • Niang Mamadou, LCV (MLI)
  • Sidibé Cheick Abou Kounta, LCV (MLI)
  • Sery Amadou, LCV (MLI)
  • Dakouo Martin, LCV (MLI)
  • El Mamy Ahmed Bezeid, ONARDEL (MRT)
  • El Arbi Ahmed Salem, ONARDEL (MRT)
  • Barry Yahya, ONARDEL (MRT)
  • Isselmou Ekaterina, ONARDEL (MRT)
  • Habiboullah Habiboullah, ONARDEL (MRT)
  • Lella Abdellahi Salem, ONARDEL (MRT)
  • Doumbia Baba, ONARDEL (MRT)
  • Baba Gueya Mohamed, ONARDEL (MRT)
  • Coste Caroline
  • Squarzoni Diaw Cécile, CIRAD-BIOS-UMR ASTRE (REU)
  • Kwiatek Olivier, CIRAD-BIOS-UMR ASTRE (FRA)
  • Libeau Geneviève, CIRAD-BIOS-UMR ASTRE (FRA)
  • Apolloni Andrea, CIRAD-BIOS-UMR ASTRE (FRA)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/598197/)

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