Inhibitory effect of Cowdria ruminantium on the expression of MHC Class I and Class II molecules on bovine endothelial cells

Vachiery Nathalie, Trap Isabelle, Totté Philippe, Martinez Dominique, Bensaïd Albert. 1998. Inhibitory effect of Cowdria ruminantium on the expression of MHC Class I and Class II molecules on bovine endothelial cells. Annals of the New York Academy of Sciences, 849 : 181-187. Biennial Conference of the Society for Tropical Veterinary Medecine. 4, Montpellier, France, 5 Mai 1997/9 Mai 1997.

Autre titre : Effet inhibiteur de Cowdria ruminantium sur l'expression des molécules MHC de classe I et de classe II sur des cellules endothéliales bovines

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Histoire et philosophie des sciences; Histoire, histoire de l'art, archéologie; Psychologie-éthologie-ergonomie

Résumé : Bovine endothelial cells constitutively express MHC class I molecules, whereas MHC class II molecules can be induced by interferon gamma (IFNy) treatment. Endothelial cells may play a role as antigen presenting cells (APC), but their role in the immune response against Cowdria ruminantium is unknown. We have studied the effect of C.ruminantium infection on the expression of MHC class I and class II molecules on the surface of bovine endothelial cells. Bovine brain endothelial cells (BBEC) from the microvasculature and bovine umbilical endothelial cells (BUEC) from the macrovasculature were cultured in vitro, infected with different concentration of Cowdria, and treated or not with IFNy. We observed that Cowdria induced a reduction of MHC molecules expression on the surface of BUEC and BBEC. This inhibitory effect of Cowdria on MHC molecules could affect the capacity of endothelial cells to act as efficient antigen-presenting cells.

Mots-clés Agrovoc : Ehrlichia ruminantium, interféron, réponse immunitaire, cellule, Rickettsia, antigène

Mots-clés complémentaires : Cellule endothéliale bovine

Classification Agris : L72 - Organismes nuisibles des animaux

Auteurs et affiliations

• Vachiery Nathalie
• Trap Isabelle ORCID: 0000-0002-3429-484X
• Totté Philippe, CIRAD-EMVT-SANTE ANIMALE (GLP)
• Martinez Dominique, CIRAD-EMVT-SANTE ANIMALE (GLP)
• Bensaïd Albert, CIRAD-EMVT-SANTE ANIMALE (GLP)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/468059/)

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