Kerdiles Yann M., Cherif Boutheina, Marie Julien C., Tremillon Nicolas, Blanquier Bariza, Libeau Geneviève, Diallo Adama, Wild T. Fabian, Villiers Marie-Bernadette, Horvat Branka. 2006. Immunomodulatory properties of Morbillivirus Nucleoproteins. Viral Immunology, 19 (2) : 324-334.
Résumé : Morbillivirus infections have been known for a long time to be associated with an acute immunosuppression in their natural hosts. Here, we show that recombinant Morbillivirus nucleoproteins from canine distemper virus, peste-des-petits-ruminants virus, and Rinderpest virus bind B-lymphocytes from dogs, goats, and cattle, respectively, similarly to measles virus nucleoprotein in humans. The use of surface plasmon resonance imaging allowed the real time detection of differential interactions between Morbillivirus nucleoproteins and Fc[gamma]RIIb (CD32). Moreover, those nucleoproteins which bind murine Fc[gamma] receptor inhibited the inflammatory immune responses in mice in a Fc receptor-dependent manner. In contrast, nucleoprotein from closely related Henipavirus genus, belonging to the Paramyxoviridae family as Morbillivirus, was devoid of capacity either to bind Fc[gamma]RIIb or to inhibit inflammatory response. Altogether, these results suggest that nucleoprotein-FcR interaction is a common mechanism used by different Morbilliviruses to modulate the immune response.
Classification Agris : L72 - Organismes nuisibles des animaux
Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes
Auteurs et affiliations
- Kerdiles Yann M., INSERM (FRA)
- Cherif Boutheina, INSERM (FRA)
- Marie Julien C., INSERM (FRA)
- Tremillon Nicolas, INSERM (FRA)
- Blanquier Bariza, INSERM (FRA)
- Libeau Geneviève, CIRAD-EMVT-UPR Contrôle des maladies (FRA)
- Diallo Adama, CIRAD-EMVT-UPR Contrôle des maladies (AUT)
- Wild T. Fabian, INSERM (FRA)
- Villiers Marie-Bernadette, INSERM (FRA)
- Horvat Branka, INSERM (FRA)
Autres liens de la publication
- Document en bibliothèque
- Localisation du document : BA_BR3382 [(Bibliothèque de Baillarguet)]
Source : Cirad - Agritrop (https://agritrop.cirad.fr/533766/)
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