Comparative genomics of three strains of Ehrlichia ruminantium : a review

Frutos Roger, Viari Alain, Ferraz Conchita, Bensaïd Albert, Morgat Anne, Boyer Frédéric, Coissac Eric, Vachiery Nathalie, Demaille Jacques, Martinez Dominique. 2006. Comparative genomics of three strains of Ehrlichia ruminantium : a review. Annals of the New York Academy of Sciences, 1081 : 417-433. Biennial Conference of the Society for Tropical Veterinary Medicine. 8, Hanoi, Viet Nam, 26 Juin 2005/1 Juillet 2005.

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Histoire et philosophie des sciences; Histoire, histoire de l'art, archéologie; Psychologie-éthologie-ergonomie

Résumé : The tick-borne Rickettsiale Ehrlichia ruminantium (E. ruminantium) is the causative agent of heartwater in Africa and the Caribbean. Heartwater, responsible for major losses on livestock in Africa represents also a threat for the American mainland. Three complete genomes corresponding to two different groups of differing phenotypes, Gardel and Welgevonden, have been recently described. One genome (Erga) represents the Gardel group from Guadeloupe Island and two genomes (Erwo and Erwe) belong to the Welgevonden group. Erwo, isolated in South Africa, is the parental strain of Erwe, which was maintained for 18 years in Guadeloupe under different culture conditions than Erwo. The three strains display genomes of differing sizes with 1,499,920 bp, 1,512,977 bp, and 1,516,355 bp for Erga, Erwe, and Erwo, respectively. Gene sequences and order are highly conserved between the three strains, although several gene truncations could be pinpointed, most of them occurring within three regions of accumulated differences (RAD). E. ruminantium displays a strong leading/lagging compositional bias inducing a strand-specific codon usage. Finally, a striking feature of E. ruminantium is the presence of long intergenic regions containing tandem repeats. These repeats are at the origin of an active process, specific to E. ruminantium, of genome expansion/contraction based on the addition or removal of tandem units.

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

• Frutos Roger, CIRAD-EMVT-UMR TRYPANOSOMES (FRA)
• Viari Alain, INRIA (FRA)
• Ferraz Conchita, IGH (FRA)
• Bensaïd Albert, CReSA (ESP)
• Morgat Anne, INRIA (FRA)
• Boyer Frédéric, INRIA (FRA)
• Coissac Eric, INRIA (FRA)
• Vachiery Nathalie, CIRAD-EMVT-UPR Contrôle des maladies (GLP)
• Demaille Jacques, IGH (FRA)
• Martinez Dominique, CIRAD-EMVT-UPR Contrôle des maladies (GLP)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/536149/)

Métriques

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