Analysis of topoisomerase mutations in fluoroquinolone-resistant and -susceptible Campylobacter jejuni strains isolated in Senegal

Dieudonné Kinana Alfred, Cardinale Eric, Bahsoun Ibrahim, Tall Fatou, Sire Jean-Marie, Garin Benoit, Cheikh Saad-Bouth Boye, Dromigny Jacques-Albert, Perrier Gros-Claude Jean David. 2007. Analysis of topoisomerase mutations in fluoroquinolone-resistant and -susceptible Campylobacter jejuni strains isolated in Senegal. International Journal of Antimicrobial Agents, 29 : 397-401.

Résumé : In this study, topoisomerase mutations in ciprofloxacin-resistant and -susceptible Campylobacter jejuni were analysed by DNA sequencing. In certain ciprofloxacin-resistant C. jejuni, the mechanism of resistance was complex. The Thr86-Ala substitution in the GyrA protein appears to play a role in increasing the minimum inhibitory concentration of nalidixic acid only. In addition, isolates with this amino acid change and those resistant to quinolones but lacking a mutation in the GyrA quinolone resistance-determining region could be derived from two different clones. Based on gyrA and gyrB polymorphisms, C. jejuni isolates from the Dakar region of Senegal appeared to be less diverse than those from other countries. Moreover, C. jejuni isolates in Senegal appeared to differ from European isolates by lack of a silent mutation at codon 120 of the gyrA gene. © 2006 Elsevier B.V. and the International Society of Chemotherapy All rights reserved.

Classification Agris : L50 - Physiologie et biochimie animales

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

• Dieudonné Kinana Alfred, Institut Pasteur de Dakar (SEN)
• Cardinale Eric, CIRAD-EMVT-UPR Systèmes d'élevage (REU) ORCID: 0000-0002-3434-3541
• Bahsoun Ibrahim, Institut Pasteur de Dakar (SEN)
• Tall Fatou, ISRA (SEN)
• Sire Jean-Marie, Institut Pasteur de Dakar (SEN)
• Garin Benoit, Institut Pasteur de Dakar (SEN)
• Cheikh Saad-Bouth Boye, Hôpital Aristide Le Dantec (SEN)
• Dromigny Jacques-Albert, Institut Pasteur de Dakar (SEN)
• Perrier Gros-Claude Jean David, Institut Pasteur de Dakar (SEN)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/537551/)

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