Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants

Perrin Aurélie, Albina Emmanuel, Breard Emmanuel, Sailleau Corinne, Prome Sylvie, Grillet Colette, Kwiatek Olivier, Russo Pierre, Thiéry Richard, Zientara Stéphan, Cetre-Sossah Catherine. 2007. Recombinant capripoxviruses expressing proteins of bluetongue virus : evaluation of immune responses and protection in small ruminants. Vaccine, 25 : 6774-6783.

Résumé : The development of recombinant capripoxviruses for protective immunization of ruminants against bluetongue virus (BTV) infection is described. Sheep (n = 11) and goats (n = 4) were immunized with BTV recombinant capripoxviruses (BTV-Cpox) individually expressing four different genes encoding two capsid proteins (VP2 and VP7) and two non-structural proteins (NS1, NS3) of BTV serotype 2 (BTV-2). Seroconversion was observed against NS3, VP7 and VP2 in both species and a lymphoproliferation specific to BTV antigens was also demonstrated in goats. Finally, partial protection of sheep challenged 3 weeks after BTV-Cpox administration with a virulent strain of BTV-2, was observed. © 2007 Elsevier Ltd All rights reserved.

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

• Perrin Aurélie, CIRAD-BIOS-UPR Contrôle des maladies (FRA)
• Albina Emmanuel, CIRAD-BIOS-UPR Contrôle des maladies (FRA)
• Breard Emmanuel, AFSSA (FRA)
• Sailleau Corinne, AFSSA (FRA)
• Prome Sylvie, CIRAD-BIOS-UPR Contrôle des maladies (FRA)
• Grillet Colette, CIRAD-BIOS-UPR Contrôle des maladies (FRA)
• Kwiatek Olivier, CIRAD-BIOS-UPR Contrôle des maladies (FRA)
• Russo Pierre, AFSSA (FRA)
• Thiéry Richard, AFSSA (FRA)
• Zientara Stéphan, AFSSA (FRA)
• Cetre-Sossah Catherine, CIRAD-BIOS-UPR Contrôle des maladies (FRA)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/540927/)

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