Garzon Edwin, Bossard Géraldine, Bras R., Totté Philippe, Rodrigues Valérie, Boulanger A., Authié Edith, Dedieu Laurence.
2007. Trypanosoma congolense heat-shock protein 70 : a promising TH1 adjuvant.
In : Does control of animal infectious risks offer a new international perspective ? : proceedings of the 12th International Conference of the Association of Institutions of Tropical Veterinary Medicine, Montpellier, France, 20-22 August 2007. Camus Emmanuel (ed.), Cardinale Eric (ed.), Dalibard Christophe (ed.), Martinez Dominique (ed.), Renard Jean-François (ed.), Roger François (ed.). CIRAD
|
Version publiée
- Anglais
Utilisation soumise à autorisation de l'auteur ou du Cirad. ID541572.pdf Télécharger (1MB) | Prévisualisation |
Résumé : Developing immunopotentiators to improve vaccine efficacy in ruminants is an important goal. Heat shock proteins (HSPs) have been shown to act as adjuvant when co-administrated with peptides antigens or given as fusion proteins. In this study, we have investigated the role of Trypanosoma congolense HSP-70 (Tcong-HSP-70) on the maturation of murine dendritic cells (DCs) generated from bone marrow precursor cells. The results obtained showed that Tcong-HSP-70 induced murine DC maturation as determined by increased levels of surface markers (CD40, CD86 and MHC II) as well as proliferation of allogeneic splenocytes. DCs exposed to Tcong-HSP-70 were characterized by strong expression of TNF[alpha] and IL-12p70 and moderate expression of IL-10. Similar study, now underway, on bovine monocyte-derived DCs demonstrated the ability of Tcong-HSP-70 to also trigger bovine Mo-DC maturation. This finding thus suggests that Tcong-HSP-70 can act as a potent Th1 adjuvant for antigen delivery.
Classification Agris : L72 - Organismes nuisibles des animaux
Auteurs et affiliations
- Garzon Edwin
- Bossard Géraldine, CIRAD-BIOS-UMR TRYPANOSOMES (FRA) ORCID: 0000-0001-9466-3101
- Bras R., IRD (FRA)
- Totté Philippe, CIRAD-BIOS-UPR Contrôle des maladies (FRA)
- Rodrigues Valérie, CIRAD-BIOS-UPR Contrôle des maladies (FRA)
- Boulanger A.
- Authié Edith, INRA (FRA)
- Dedieu Laurence, CIRAD-BIOS-UPR Contrôle des maladies (FRA) ORCID: 0000-0002-6492-3002
Autres liens de la publication
Source : Cirad - Agritrop (https://agritrop.cirad.fr/541572/)
[ Page générée et mise en cache le 2024-12-19 ]