Emergence of a new genetic lineage of Newcastle disease virus in West and Central Africa-Implications for diagnosis and control

Cattoli Giovanni, Fusari Alessandro, Monne Isabella, Molia Sophie, Le Menach A., Maregeya B., Nchare A., Bangana I., Garba Maina A., N'Goran Koffi Jean Narcisse, Thiam H., Bezeid Ould El Mamy, Salviato A., Nisi Raffaella, Terregino C., Capua Ilaria. 2010. Emergence of a new genetic lineage of Newcastle disease virus in West and Central Africa-Implications for diagnosis and control. Veterinary Microbiology, 142 (1) : 168-176.

Quartile : Outlier, Sujet : VETERINARY SCIENCES / Quartile : Q2, Sujet : MICROBIOLOGY

Résumé : Newcastle disease (ND) is an OIE listed disease caused by virulent avian paramyxovirus type 1 (APMV-1) strains, which affect many species of birds and may cause severe economic losses in the poultry sector. The disease has been officially and unofficially reported in many African countries and still remains the main poultry disease in commercial and rural chickens of Africa. Unfortunately, virological and epidemiological information concerning ND strains circulating in the Western and Central regions of Africa is extremely scarce. In the present study, sequence analysis, pathotyping and detailed genetic characterization of virulent ND strains detected in rural poultry in West and Central Africa revealed the circulation of a new genetic lineage, distinguishable from the lineages described in the Eastern and Southern parts of the continent. Severalmismatches were observed in the segment of the matrix gene targeted by the primers and probe designed for the molecular detection of APMV-1, which were responsible for the false negative results in the diagnostic test conducted. Furthermore, deduced amino acid sequences of the two major antigens eliciting a protective immune response (F and HN glycoprotein) revealed protein similarities <90% if compared to some common vaccine strains. Distinct mutations located in the neutralizing epitopes were revealed, indicating the need for detailed assessment of the efficacy of the current vaccines and vaccination practices in Africa. The present investigation provides important information on the epidemiology, diagnosis and control of NDV in Africa and highlights the importance of supporting surveillance in developing countries for transboundary animal diseases.

Mots-clés Agrovoc : virus maladie de newcastle, volaille, maladie de Newcastle, Paramyxovirus aviaire, diagnostic, contrôle de maladies, variation génétique

Mots-clés géographiques Agrovoc : Afrique centrale, Afrique occidentale

Mots-clés complémentaires : Émergence

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

• Cattoli Giovanni, Istituto zooprofilattico sperimentale delle Venezie (ITA)
• Fusari Alessandro, Istituto zooprofilattico sperimentale delle Venezie (ITA)
• Monne Isabella, Istituto zooprofilattico sperimentale delle Venezie (ITA)
• Molia Sophie, CIRAD-ES-UPR AGIRs (MLI) ORCID: 0000-0002-5695-7464
• Le Menach A., FAO (ITA)
• Maregeya B., FAO (BDI)
• Nchare A., Ministère de l'élevage des pêches et des industries animales (Niger) (NER)
• Bangana I., Ministère des ressources animales (Niger) (NER)
• Garba Maina A., FAO (CIV)
• N'Goran Koffi Jean Narcisse, Label Ivoire Elevage (CIV)
• Thiam H.
• Bezeid Ould El Mamy, CNERV (MRT)
• Salviato A., Istituto zooprofilattico sperimentale delle Venezie (ITA)
• Nisi Raffaella, Istituto zooprofilattico sperimentale delle Venezie (ITA)
• Terregino C., Istituto zooprofilattico sperimentale delle Venezie (ITA)
• Capua Ilaria, Istituto zooprofilattico sperimentale delle Venezie (ITA)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/554872/)

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