Comparative analysis of four lipoproteins from Mycoplasma mycoides subsp. mycoides small colony identifies LppA as a major T-cell antigen

Dedieu Laurence, Totté Philippe, Rodrigues Valérie, Vilei Edy M., Frey Joachim. 2010. Comparative analysis of four lipoproteins from Mycoplasma mycoides subsp. mycoides small colony identifies LppA as a major T-cell antigen. Comparative Immunology, Microbiology and Infectious Diseases, 33 (4) : 279-290.

Quartile : Outlier, Sujet : VETERINARY SCIENCES / Quartile : Q2, Sujet : MICROBIOLOGY / Quartile : Q2, Sujet : IMMUNOLOGY

Résumé : Control of contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides Small Colony (MmmSC), remains an important goal in Africa. Subunit vaccines triggering B and T-cell responses could represent a promising approach. To this aim, the T-cell immunogenicity of four MmmSC lipoproteins (LppA, LppB, LppC and LppQ), present in African strains and able to elicit humoral response, was evaluated. In vitro assays revealed that only LppA was recognized by lymph node lymphocytes taken from three cattle, 3 weeks after MmmSC exposure. Maintenance of the LppA-specific response, relying on CD4 T-cells and IFNg production, was then demonstrated 1 year after infection. LppA is thus an important target for the CD4 T-cells generated early after MmmSC infection and persisting in the lymph nodes of recovered cattle. Its role as a protective antigen and ability to in vivo trigger both arms of the host immune response remain to be evaluated.

Mots-clés Agrovoc : Mycoplasma mycoides, bovin, péripneumonie contagieuse bovine, antigène, lipoprotéine, immunité cellulaire, vaccin, immunologie, zone tropicale, bétail, épidémiologie

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

• Dedieu Laurence, CIRAD-BIOS-UPR Contrôle des maladies (FRA) ORCID: 0000-0002-6492-3002
• Totté Philippe, CIRAD-BIOS-UMR CMAEE (FRA)
• Rodrigues Valérie, CIRAD-BIOS-UMR CMAEE (FRA)
• Vilei Edy M., Institut de bactériologie vétérinaire (CHE)
• Frey Joachim, Institut de bactériologie vétérinaire (CHE)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/556404/)

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