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Revisiting the Immune trypanolysis test to optimise epidemiological surveillance and control of sleeping sickness in West Africa

Jamonneau Vincent, Bucheton Bruno, Kaboré Jacques, Ilboudo Hamidou, Camara Oumou, Courtin Fabrice, Solano Philippe, Kaba Dramane, Kambire Roger, Lingue Kouakou, Camara Mamadou, Baelmans Rudy, Lejon Veerle, Büscher Philippe. 2010. Revisiting the Immune trypanolysis test to optimise epidemiological surveillance and control of sleeping sickness in West Africa. PLoS Neglected Tropical Diseases, 6 (12):e977, 8 p.

Journal article ; Article de revue à facteur d'impact Revue en libre accès total
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Quartile : Q1, Sujet : TROPICAL MEDICINE / Quartile : Q1, Sujet : PARASITOLOGY

Abstract : Background: Because of its high sensitivity and its ease of use in the field, the card agglutination test for trypanosomiasis (CATT) is widely used for mass screening of sleeping sickness. However, the CATT exhibits false-positive results (i) raising the question of whether CATT-positive subjects who are negative in parasitology are truly exposed to infection and (ii) making it difficult to evaluate whether Trypanosoma brucei (T.b.) gambiense is still circulating in areas of low endemicity. The objective of this study was to assess the value of the immune trypanolysis test (TL) in characterising the HAT status of CATT-positive subjects and to monitor HAT elimination in West Africa. Methodology/Principal Findings: TL was performed on plasma collected from CATT-positive persons identified within medical surveys in several West African HAT foci in Guinea, Co¿ te d'Ivoire and Burkina Faso with diverse epidemiological statuses (active, latent, or historical). All HAT cases were TL+. All subjects living in a nonendemic area were TL2. CATT prevalence was not correlated with HAT prevalence in the study areas, whereas a significant correlation was found using TL. Conclusion and Significance: TL appears to be a marker for contact with T.b. gambiense. TL can be a tool (i) at an individual level to identify nonparasitologically confirmed CATT-positive subjects as well as those who had contact with T.b. gambiense and should be followed up, (ii) at a population level to identify priority areas for intervention, and (iii) in the context of HAT elimination to identify areas free of HAT. (Résumé d'auteur)

Mots-clés Agrovoc : Trypanosoma brucei, Test biologique, Sérologie, Agglutination immunologique, Surveillance épidémiologique, Contrôle de maladies, Trypanosomose, Diagnostic

Mots-clés géographiques Agrovoc : Guinée, Burkina Faso, Côte d'Ivoire, Afrique occidentale

Mots-clés complémentaires : Trypanosoma brucei gambiense

Classification Agris : L73 - Animal diseases
U30 - Research methods

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Jamonneau Vincent, CIRDES (BFA)
  • Bucheton Bruno, CIRAD-EMVT-UMR TRYPANOSOMES (BFA)
  • Kaboré Jacques, CIRDES (BFA)
  • Ilboudo Hamidou, CIRDES (BFA)
  • Camara Oumou, CIRDES (BFA)
  • Courtin Fabrice, CIRDES (BFA)
  • Solano Philippe, IRD (BFA)
  • Kaba Dramane, IPR (CIV)
  • Kambire Roger, Programme national de la lutte contre la trypanosomiase humaine africaine (BFA)
  • Lingue Kouakou, Programme national d'élimination de la trypanosomiase humaine africaine (CIV)
  • Camara Mamadou, PNLTHA (GIN)
  • Baelmans Rudy, Institute of tropical medecine (BEL)
  • Lejon Veerle, Institute of tropical medecine (BEL)
  • Büscher Philippe, Institute of tropical medecine (BEL)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/558883/)

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