Can human movements explain heterogeneous propagation of dengue fever in Cambodia?

Teurlai Magali, Huy Rekol, Cazelles Bernard, Duboz Raphaël, Baehr Christophe, Vong Sirenda. 2012. Can human movements explain heterogeneous propagation of dengue fever in Cambodia?. PLoS Neglected Tropical Diseases, 6 (12):e1957, 8 p.

Quartile : Q1, Sujet : TROPICAL MEDICINE / Quartile : Q1, Sujet : PARASITOLOGY

Résumé : Background: Determining the factors underlying the long-range spatial spread of infectious diseases is a key issue regarding their control. Dengue is the most important arboviral disease worldwide and a major public health problem in tropical areas. However the determinants shaping its dynamics at a national scale remain poorly understood. Here we describe the spatial-temporal pattern of propagation of annual epidemics in Cambodia and discuss the role that human movements play in the observed pattern. Methods and Findings: We used wavelet phase analysis to analyse time-series data of 105,598 hospitalized cases reported between 2002 and 2008 in the 135 (/180) most populous districts in Cambodia. We reveal spatial heterogeneity in the propagation of the annual epidemic. Each year, epidemics are highly synchronous over a large geographic area along the busiest national road of the country whereas travelling waves emanate from a few rural areas and move slowly along the Mekong River at a speed of ,11 km per week (95% confidence interval 3-18 km per week) towards the capital, Phnom Penh. Conclusions: We suggest human movements - using roads as a surrogate - play a major role in the spread of dengue fever at a national scale. These findings constitute a new starting point in the understanding of the processes driving dengue spread.

Mots-clés Agrovoc : flavivirus, transmission des maladies, migration, genre humain

Mots-clés géographiques Agrovoc : Cambodge

Mots-clés complémentaires : Virus de la dengue

Classification Agris : L73 - Maladies des animaux
E51 - Population rurale

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

• Teurlai Magali, Institut Pasteur du Cambodge (KHM)
• Huy Rekol, Ministère de la santé (Cambodge) (KHM)
• Cazelles Bernard, CNRS (FRA)
• Duboz Raphaël, CIRAD-ES-UPR AGIRs (THA) ORCID: 0000-0002-2853-6195
• Baehr Christophe, CNRM (FRA)
• Vong Sirenda, Institut Pasteur du Cambodge (KHM)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/567015/)

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