Characterization of anamnestic T-cell responses induced by conventional vaccines against contagious bovine pleuropneumonia

Totté Philippe, YaYa Aboubakar, Sery Amadou, Wesonga Hezron, Wade Abel, Naessens Jan, Niang Mamadou, Thiaucourt François. 2013. Characterization of anamnestic T-cell responses induced by conventional vaccines against contagious bovine pleuropneumonia. PloS One, 8 (2):e57509, 6 p.

https://doi.org/10.1371/journal.pone.0057509

Article de revue ; Article de revue à facteur d'impact Revue en libre accès total

Prévisualisation

Version publiée - Anglais
Utilisation soumise à autorisation de l'auteur ou du Cirad.
document_568452.pdf
Télécharger (671kB) | Prévisualisation

Quartile : Outlier, Sujet : MULTIDISCIPLINARY SCIENCES

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie; Staps

Résumé : A better understanding of how T1 vaccination confers immunity would facilitate the rational design of improved vaccines against contagious bovine pleuropneumonia (CBPP). We show here that mycoplasmas-induced recall proliferation and IFN-c responses are detected in cattle that received multiple shots of T1 vaccines. These anamnestic responses were under the strict control of CD4+ T lymphocytes. Moreover, CD62L expression indicated that both CD4+ effector memory (Tem) and central memory (Tcm) T lymphocytes are elicited in these animals. Comparative analysis with data from cattle that completely recovered from CBPP infection revealed similar anamnestic T-cell responses albeit at a lower magnitude for T1- vaccinated animals, particularly in the Tcm compartment. In conclusion, we discuss how our current understanding of T-cell responses will contribute to ongoing efforts for the improvement of future CBPP vaccines.

Mots-clés Agrovoc : péripneumonie contagieuse bovine, Mycoplasma mycoides, bovin, vaccin, immunologie, lymphocyte, réponse immunitaire, vaccination

Mots-clés géographiques Agrovoc : Cameroun, Kenya, Mali

Mots-clés complémentaires : Production de vaccin

Classification Agris : L73 - Maladies des animaux
L50 - Physiologie et biochimie animales

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations