Complex dynamic of dengue virus serotypes 2 and 3 in Cambodia following series of climate disasters

Duong Veasna, Henn Matthew R., Simmons Cameron, Chantha Ngan, Bunthin Y, Gavotte Laurent, Viari Alain, Ong Sivuth, Huy Rekol, Lennon Niall J., Ly Sowath, Vong Sirenda, Birren Bruce W., Farrar Jeremy J., Deubel Vincent, Frutos Roger, Buchy Philippe. 2013. Complex dynamic of dengue virus serotypes 2 and 3 in Cambodia following series of climate disasters. Infection, Genetics and Evolution, 15, spec. : pp. 77-86. International Giardia and Cryptosporidium Conference. 4, Wellington, Afrique du Sud, 30 January 2012/3 February 2012.

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Quartile : Q2, Sujet : INFECTIOUS DISEASES

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Anthropologie-Ethnologie

Abstract : The Dengue National Control Program was established in Cambodia in 2000 and has reported between 10,000 and 40,000 dengue cases per year with a case fatality rate ranging from 0.7 to 1.7. In this study 39 DENV-2 and 57 DENV-3 viruses isolated from patients between 2000 and 2008 were fully sequenced. Five DENV2 and four DENV3 distinct lineages with different dynamics were identified. Each lineage was characterized by the presence of specific mutations with no evidence of recombination. In both DENV-2 and DENV-3 the lineages present prior to 2003 were replaced after that date by unrelated lineages. After 2003, DENV-2 lineages D2-3 and D2-4 cocirculated until 2007 when they were almost completely replaced by a lineage D2-5 which emerged from D2-3 Conversely, all DENV-3 lineages remained, diversified and cocirculated with novel lineages emerging. Years 2006 and 2007 were marked by a high prevalence of DENV-3 and 2007 with a large dengue outbreak and a high proportion of patients with severe disease. Selective sweeps in DENV-1 and DENV-2 were linked to immunological escape to a predominately DENV-3-driven immunological response. The complex dynamic of dengue in Cambodia in the last ten years has been associated with a combination of stochastic climatic events, cocirculation, coevolution, adaptation to different vector populations, and with the human population immunological landscape. (Résumé d'auteur)

Mots-clés Agrovoc : Flavivirus, épidémie, Sérotype, Descendance, Variation génétique, Catastrophe naturelle, Accident climatique, Facteur climatique, Lignée

Mots-clés géographiques Agrovoc : Cambodge

Mots-clés complémentaires : Virus de la dengue

Classification Agris : L73 - Animal diseases
000 - Other themes

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Duong Veasna, Institut Pasteur du Cambodge (KHM)
  • Henn Matthew R., Oxford University (VNM)
  • Simmons Cameron, Oxford University (VNM)
  • Chantha Ngan, National Center of Parasitology (KHM)
  • Bunthin Y, Institut Pasteur du Cambodge (KHM)
  • Gavotte Laurent, UM2 (FRA)
  • Viari Alain, INRIA (FRA)
  • Ong Sivuth, Institut Pasteur du Cambodge (KHM)
  • Huy Rekol, Ministère de la santé (Cambodge) (KHM)
  • Lennon Niall J., Broad Institut (USA)
  • Ly Sowath, Institut Pasteur du Cambodge (KHM)
  • Vong Sirenda, Institut Pasteur du Cambodge (KHM)
  • Birren Bruce W., Broad Institut (USA)
  • Farrar Jeremy J., Oxford University (VNM)
  • Deubel Vincent, Institut Pasteur du Cambodge (KHM)
  • Buchy Philippe, Institut Pasteur du Cambodge (KHM)

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