A fatal neuroinvasive west nile virus infection in a traveler returning from Madagascar: Clinical, epidemiological and veterinary investigations

Larrieu Sophie, Cardinale Eric, Ocquidant Philippe, Roger Matthieu, Lepec Richard, Delatte Hélène, Camuset Guillaume, Despres Philippe, Brottet Elise, Charlin Cyril, Michault Alain. 2013. A fatal neuroinvasive west nile virus infection in a traveler returning from Madagascar: Clinical, epidemiological and veterinary investigations. American Journal of Tropical Medicine and Hygiene, 89 (2) : 211-213.

https://doi.org/10.4269/ajtmh.12-0003

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Quartile : Q1, Sujet : TROPICAL MEDICINE / Quartile : Q1, Sujet : PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH (Science)

Résumé : A 58-year-old woman living in Reunion Island and returning from Madagascar was hospitalized for neuroinvasive encephalitis and died 1 month later. West Nile virus (WNV) infection was biologically confirmed by detection of immunoglobulin M (IgM) reactive with WNV antigens in both cerebrospinal fluid and serum, and weak neutralizing activity was also detected. A veterinary survey performed in her traveling area showed a seroprevalence of WNV of 28.7% (95% confidence interval [CI] = 21.1-36.3) in adult poultry, confirming an active circulation of the virus. Development of a severe form could be related to a weak antibody response, because the patient presented low IgM and IgG titers. This case report underlines the constant risk of emergence of West Nile in Indian Ocean territories, including Reunion Island where competent vectors are widely present during the whole year.

Mots-clés Agrovoc : encéphalite, flavivirus, genre humain, mortalité, transmission des maladies, épidémiologie, maladie de l'homme, étude de cas

Mots-clés géographiques Agrovoc : Madagascar, La Réunion, France

Mots-clés complémentaires : Fièvre du Nil occidental, Émergence

Classification Agris : L73 - Maladies des animaux
S50 - Santé humaine

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

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