Atypical human infections by animal trypanosomes

Truc Philippe, Büscher Philippe, Cuny Gérard, Gonzatti Marisa, Jannin Jean, Joshi Prashant, Juyal Prayag, Lun Zhao-Rong, Mattioli Raffaele C., Pays Etienne, Simarro Pere P., Geraldes Teixeiras Marta Maria, Touratier Louis, Vincendeau Philippe, Desquesnes Marc. 2013. Atypical human infections by animal trypanosomes. PLoS Neglected Tropical Diseases, 7 (9):e2208, 7 p.

https://doi.org/10.1371/journal.pntd.0002256

Article de revue ; Article de revue à facteur d'impact Revue en libre accès total

Prévisualisation

Version publiée - Anglais
Utilisation soumise à autorisation de l'auteur ou du Cirad.
document_572135.pdf
Télécharger (411kB) | Prévisualisation

Quartile : Q1, Sujet : TROPICAL MEDICINE / Quartile : Q1, Sujet : PARASITOLOGY

Résumé : The two classical forms of human trypanoso- moses are sleeping sickness due to Trypanosoma brucei gambiense or T. brucei rhodesiense , and Chagas disease due to T. cruzi . However, a number of atypical human infections caused by other T. species (or sub-species) have been reported, namely due to T. brucei brucei , T. vivax , T. congolense , T. evansi , T. lewisi , and T. lewisi -like. These cases are reviewed here. Some infections were transient in nature, while others required treatments that were successful in most cases, although two cases were fatal. A recent case of infection due to T. evansi was related to a lack of apolipoprotein L-I, but T. lewisi infections were not related to immunosuppression or specific human genetic profiles. Out of 19 patients, eight were confirmed between 1974 and 2010, thanks to improved molecular techniques. However, the number of cases of atypical human trypanosomoses might be underestimated. Thus, improvement, evaluation of new diagnostic tests, and field investigations are required for detection and confirmation of these atypical cases.

Mots-clés Agrovoc : trypanosomose, genre humain, maladie de l'homme, maladie des animaux, diagnostic, analyse du risque, technique immunologique, rongeur, identification, Trypanosoma, Trypanosoma brucei, Trypanosoma evansi, Trypanosoma lewisi, Trypanosoma congolense