MBT/Pas mouse: A relevant model for the evaluation of Rift Valley fever vaccines

Ayari-Fakhfakh Saïda Emna, Zaverucha do Valle Tânia, Guillemot Laurent, Panthier Jean-Jacques, Bouloy Michèle, Ghram Abdeljelil, Albina Emmanuel, Cetre-Sossah Catherine. 2012. MBT/Pas mouse: A relevant model for the evaluation of Rift Valley fever vaccines. Journal of General Virology, 93 (7) : 1456-1464.

Quartile : Q2, Sujet : BIOTECHNOLOGY & APPLIED MICROBIOLOGY / Quartile : Q2, Sujet : VIROLOGY

Résumé : Currently, there are no worldwide licensed vaccines for Rift Valley fever (RVF) that are both safe and effective. Development and evaluation of vaccines, diagnostics and treatments depend on the availability of appropriate animal models. Animal models are also necessary to understand the basic pathobiology of infection. Here, we report the use of an inbred MBT/Pas mouse model that consistently reproduces RVF disease and serves our purpose for testing the efficacy of vaccine candidates; an attenuated Rift Valley fever virus (RVFV) and a recombinant RVFV-capripoxvirus. We show that this model is relevant for vaccine testing.

Mots-clés Agrovoc : Virus de la fièvre de la vallée du Rift, contrôle de maladies, souris, modèle, vaccin vivant, vaccin, efficacité, testage, fièvre de la Vallée du Rift

Mots-clés géographiques Agrovoc : Tunisie

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

• Ayari-Fakhfakh Saïda Emna, Institut Pasteur de Tunis (TUN)
• Zaverucha do Valle Tânia, Institut Pasteur (FRA)
• Guillemot Laurent, Institut Pasteur (FRA)
• Panthier Jean-Jacques, Institut Pasteur (FRA)
• Bouloy Michèle, Institut Pasteur (FRA)
• Ghram Abdeljelil, Institut Pasteur de Tunis (TUN)
• Albina Emmanuel, CIRAD-BIOS-UMR CMAEE (FRA)
• Cetre-Sossah Catherine, CIRAD-BIOS-UMR CMAEE (FRA)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/572697/)

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