Michael reactions carried out using a bench-top flow system

Bonfils Frédéric, Cazaux Isabelle, Hodge Philip, Caze Claude. 2006. Michael reactions carried out using a bench-top flow system. Organic and Biomolecular Chemistry (3) : 493-497.

Résumé : The Michael reaction between methyl 1-oxoindan-2-carboxylate and methyl vinyl ketone was achieved successfully by pumping solutions of the reactants in toluene through a fluid bed of Amberlyst A21 at 50 °C. The use of a fluid bed reactor is attractive as it allows gel-type beads, i.e. the type of bead used in most studies of polymer-supported (PS) organic reactions, to be used satisfactorily in a flow system. When polymer-supported cinchonidine was used in place of Amberlyst A21, the Michael product was obtained in high yield with an enantiomeric excess (ee) of 51%. This % ee is comparable to that achieved when the reaction was catalysed by cinchonidine itself.

Classification Agris : 000 - Autres thèmes
Q60 - Traitement des produits agricoles non alimentaires

Champ stratégique Cirad : Hors axes (2005-2013)

Auteurs et affiliations

• Bonfils Frédéric, CIRAD-CP-UPR Qualité produits pérennes (FRA) ORCID: 0000-0001-7016-4770
• Cazaux Isabelle, University of Manchester (GBR)
• Hodge Philip, University of Manchester (GBR)
• Caze Claude, CNRS (FRA)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/578155/)

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