Negative purifying selection drives prion and doppel protein evolution

Tsangaras Kyriakos, Kolokotronis Sergios-Orestis, Ulrich Rainer G., Morand Serge, Michaux Johan, Greenwood Alex. 2014. Negative purifying selection drives prion and doppel protein evolution. Journal of Molecular Evolution, 79 (1-2) : 12-20.

Quartile : Q3, Sujet : GENETICS & HEREDITY / Quartile : Q4, Sujet : EVOLUTIONARY BIOLOGY / Quartile : Q4, Sujet : BIOCHEMISTRY & MOLECULAR BIOLOGY

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Résumé : The prion protein (PrP) when misfolded into the pathogenic conformer PrPSc is the major causative agent of several lethal transmissible spongiform encephalopathies in mammals. Studies of evolutionary pressure on the corresponding gene using different datasets have yielded conflicting results. In addition, putative PrP or PrP interacting partners with strong similarity to PrP such as the doppel protein have not been examined to determine if the same evolutionary mechanisms apply to prion paralogs or if there are coselected sites that might indicate how and where the proteins interact. We examined several taxonomic groups that contain model organisms of prion diseases focusing on primates, bovids, and an expanded dataset of rodents for selection pressure on the prion gene (PRNP) and doppel gene (PRND) individually and for coevolving sites within. Overall, the results clearly indicate that both proteins are under strong selective constraints with relaxed selection on amino acid residues connecting α-helices 1 and 2.

Mots-clés géographiques Agrovoc : Asie du Sud-Est, Europe

Classification Agris : L73 - Maladies des animaux
S50 - Santé humaine

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

• Tsangaras Kyriakos, Leibniz IZW (DEU)
• Kolokotronis Sergios-Orestis, Fordham University (USA)
• Ulrich Rainer G., FLI (DEU)
• Morand Serge, CIRAD-ES-UPR AGIRs (LAO) ORCID: 0000-0003-3986-7659
• Michaux Johan, CIRAD-ES-UPR AGIRs (FRA)
• Greenwood Alex, Leibniz IZW (DEU)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/578570/)

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