Endogenous gibbon ape leukemia virus (GALV) identified in a rodent (Melomys burtoni subsp.) from Wallacea (Indonesia)

Alfano Niccolo, Michaux Johan, Morand Serge, Aplin Ken, Tsangaras Kyriakos, Löber Ulrike, Fabre Pierre-Henri, Fitriana Yuli, Semiadi Gono, Ishida Yasuko, Helgen Kristofer M., Roca Alfred L., Eiden Maribeth V., Greenwood Alex. 2016. Endogenous gibbon ape leukemia virus (GALV) identified in a rodent (Melomys burtoni subsp.) from Wallacea (Indonesia). Journal of Virology, 90 (18) : 8169-8180.

Url - jeu de données - Entrepôt autre : http://www.ncbi.nlm.nih.gov/nuccore/KX059700

Quartile : Q1, Sujet : VIROLOGY

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Résumé : Gibbon ape leukemia virus (GALV) and koala retrovirus (KoRV) most likely originated from a cross-species transmission of an ancestral retrovirus into koalas and gibbons via one or more intermediate as yet unknown hosts. A highly similar virus to GALV has been identified in an Australian native rodent (Melomys burtoni) after extensive screening of Australian wildlife. GALV-like viruses have also been discovered in several Southeast Asian species although screening has not been extensive and viruses discovered to date are only distantly related to GALV. We therefore screened 26 Southeast Asian rodent species for KoRV- and GALV-like sequences, using hybridization capture and high-throughput sequencing, in the attempt to identify potential GALV and KoRV hosts. Only the individuals belonging to a newly discovered subspecies of Melomys burtoni from Indonesia were positive yielding an endogenous provirus very closely related to a strain of GALV. The sequence of the critical receptor domain for GALV infection in the Indonesian M. burtoni subsp. was consistent with the susceptibility of the species to GALV infection. The second record of a GALV in M. burtoni provides further evidence that M. burtoni, and potentially other lineages within the widespread subfamily Murinae, may play a role in the spread of GALV-like viruses. The discovery of a GALV in the most western part of the Australo-Papuan distribution of M. burtoni, specifically in a transitional zone between Asia and Australia (Wallacea), may be relevant to the cross-species transmission to gibbons in Southeast Asia and broadens the known distribution of GALVs in wild rodents.

Mots-clés géographiques Agrovoc : Indonésie

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

• Alfano Niccolo, Leibniz IZW (DEU)
• Michaux Johan, Université de Liège (BEL)
• Morand Serge, CIRAD-ES-UPR AGIRs (LAO) ORCID: 0000-0003-3986-7659
• Aplin Ken, National Museum of Natural History (USA)
• Tsangaras Kyriakos, Leibniz IZW (DEU)
• Löber Ulrike, Leibniz IZW (DEU)
• Fabre Pierre-Henri, Smithsonian Institution (USA)
• Fitriana Yuli, LIPI (IDN)
• Semiadi Gono, LIPI (IDN)
• Ishida Yasuko, University of Illinois (USA)
• Helgen Kristofer M., Smithsonian Institution (USA)
• Roca Alfred L., University of Illinois (USA)
• Eiden Maribeth V., Freie Universitaet Berlin (DEU)
• Greenwood Alex, Leibniz IZW (DEU)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/581081/)

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