Holzmuller Philippe, Nirdé Philippe, Vezilier Frédéric, Chuchana Paul. 2016. The transcriptomic analytical level determines the human monocyte-derived macrophage response toward either the infectious agent or the host. Infection, Genetics and Evolution, 45 : 426-433.
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Version publiée
- Anglais
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Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE69964
Quartile : Q2, Sujet : INFECTIOUS DISEASES
Liste HCERES des revues (en SHS) : oui
Thème(s) HCERES des revues (en SHS) : Anthropologie-Ethnologie
Résumé : Macrophages exhibit multifunctional activity and play a central role in the response to infectious agents. It is commonly accepted that the plasticity of the response of macrophages depends on the type of stimuli. Here we re-evaluate whether the macrophage response is only dependent on the stimulus. We analyzed the transcriptomic profile of monocyte-derived macrophages (MDMs) that were activated with several pathogens and multiple in vitro-stimulations. The transcriptomic data were normalized using matched-pair analysis. Further analysis showed a clustering association with (i) specific signatures of the infectious agent and its strategy as well as (ii) a preponderance of MDM overall responses related to individuals. Currently, the null hypothesis H0 is that the innate MDM response is globally associated with the pathogen. Our results reveal that the global innate MDM response is intrinsically and predominantly associated with the individual. Thus, the hypothesis is supported or negated depending on the transcriptomic analytical level.
Classification Agris : S50 - Santé humaine
L73 - Maladies des animaux
Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes
Auteurs et affiliations
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Holzmuller Philippe, CIRAD-BIOS-UMR CMAEE (FRA)
ORCID: 0000-0002-8919-9081
- Nirdé Philippe, INSERM (FRA)
- Vezilier Frédéric, IRD (FRA)
- Chuchana Paul, INSERM (FRA)
Source : Cirad-Agritrop (https://agritrop.cirad.fr/582698/)
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