Proteinuria during dengue fever in children

Andries Anne-Claire, Duong Veasna, Cappelle Julien, Ong Sivuth, Kerleguer Alexandra, Ly Sowath, Tarantola Arnaud, Horwood Paul, Sakuntabhai Anavaj, Dussart Philippe, Buchy Philippe. 2017. Proteinuria during dengue fever in children. International Journal of Infectious Diseases, 55 : 38-44.

https://doi.org/10.1016/j.ijid.2016.12.022

Article de revue ; Article de recherche ; Article de revue à facteur d'impact

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Quartile : Q2, Sujet : INFECTIOUS DISEASES

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Résumé : Objectives: This study aimed to investigate proteinuria occurring during dengue disease in children and assess if measurement of this parameter can help physicians in the clinical management of patients. Methods: Proteinuria was assessed by dipstick and quantified by urine protein:creatinine ratio (UPCR) in samples from patients hospitalized with a confirmed dengue infection and in healthy controls. Results: The dipstick tested positive in 42.9% of the patients presenting at hospital with dengue versus 20.0% in healthy controls. UPCR increased during the critical phase of the disease; peaking one week after fever onset then decreasing as the patients recovered. Patients with warnings signs or severe dengue were more likely to present with proteinuria detected by UPCR at the time of hospital admission compared to patients without warning signs. The sensitivity of this marker, however, was limited as only 16.1% of the patients with warning signs had proteinuria. Conclusions: Urine dipstick and UPCR do not seem to be very valuable for the triage of the patients at the time of the initial consultation but the observation of a decrease of the UPCR during the course of the illness appears to indicate an evolution towards recovery.

Mots-clés Agrovoc : flavivirus, enfant, protéinurie, créatinine, urine, électrophorèse, diagnostic, infection

Mots-clés géographiques Agrovoc : Pays de l'Union européenne, Cambodge

Mots-clés complémentaires : Virus de la dengue

Classification Agris : 000 - Autres thèmes
L73 - Maladies des animaux
U30 - Méthodes de recherche

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Agences de financement européennes : European Commission

Programme de financement européen : FP7

Projets sur financement : (EU) Dengue research Framework for Resisting Epidemics in Europe

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