Drivers of Rift Valley fever epidemics in Madagascar

Lancelot Renaud, Beral Marina, Rakotoharinome Vincent Michel, Andriamandimby Soa Fy, Héraud Jean Michel, Coste Caroline, Apolloni Andrea, Squarzoni Cécile, De La Rocque Stéphane, Formenty Pierre, Bouyer Jérémy, Wint Willy, Cardinale Eric. 2017. Drivers of Rift Valley fever epidemics in Madagascar. Proceedings of the National Academy of Sciences of the United States of America, 114 (5) : 938-943.

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Quartile : Outlier, Sujet : MULTIDISCIPLINARY SCIENCES

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Economie-gestion; Psychologie-éthologie-ergonomie

Résumé : Rift Valley fever (RVF) is a vector-borne viral disease widespread in Africa. The primary cycle involves mosquitoes and wild and domestic ruminant hosts. Humans are usually contaminated after contact with infected ruminants. As many environmental, agricultural, epidemiological, and anthropogenic factors are implicated in RVF spread, the multidisciplinary One Health approach was needed to identify the drivers of RVF epidemics in Madagascar. We examined the environmental patterns associated with these epidemics, comparing human and ruminant serological data with environmental and cattle-trade data. In contrast to East Africa, environmental drivers did not trigger the epidemics: They only modulated local Rift Valley fever virus (RVFV) transmission in ruminants. Instead, RVFV was introduced through ruminant trade and subsequent movement of cattle between trade hubs caused its long-distance spread within the country. Contact with cattle brought in from infected districts was associated with higher infection risk in slaughterhouse workers. The finding that anthropogenic rather than environmental factors are the main drivers of RVF infection in humans can be used to design better prevention and early detection in the case of RVF resurgence in the region.

Mots-clés Agrovoc : Virus de la fièvre de la vallée du Rift, vecteur de maladie, zoonose, transmission des maladies, analyse du risque, épidémiologie, genre humain, bétail, bovin, ruminant, facteur de risque, facteur du milieu, marketing, Enquête pathologique, sérum sanguin, surveillance épidémiologique, contrôle de maladies, fièvre de la Vallée du Rift

Mots-clés géographiques Agrovoc : Madagascar

Mots-clés complémentaires : Émergence

Mots-clés libres : Vector-borne infection, Zoonosis, El Niño, Cattle trade, One health

Classification Agris : L73 - Maladies des animaux
L72 - Organismes nuisibles des animaux
000 - Autres thèmes

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Agences de financement européennes : European Commission

Programme de financement européen : FP7

Projets sur financement : (EU) Emerging viral vector borne diseases

Auteurs et affiliations

• Lancelot Renaud, CIRAD-BIOS-UMR CMAEE (FRA) ORCID: 0000-0002-5826-5242
• Beral Marina, INRA (FRA)
• Rakotoharinome Vincent Michel, Ministère de l'élevage (Madagascar) (MDG)
• Andriamandimby Soa Fy, Institut Pasteur de Madagascar (MDG)
• Héraud Jean Michel, Institut Pasteur de Madagascar (MDG)
• Coste Caroline, CIRAD-BIOS-UMR CMAEE (FRA)
• Apolloni Andrea, CIRAD-BIOS-UMR CMAEE (SEN) ORCID: 0000-0002-0228-2086
• Squarzoni Cécile, CIRAD-BIOS-UMR CMAEE (FRA)
• De La Rocque Stéphane, CIRAD-BIOS-UMR ASTRE (CHE)
• Formenty Pierre, OMS (CHE)
• Bouyer Jérémy, CIRAD-BIOS-UMR CMAEE (ETH) ORCID: 0000-0002-1913-416X
• Wint Willy, ERGO (GBR)
• Cardinale Eric, CIRAD-BIOS-UPR Contrôle des maladies (REU) ORCID: 0000-0002-3434-3541

Source : Cirad-Agritrop (https://agritrop.cirad.fr/583139/)

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