Perrone Trina, Aso Pedro Maria, Mijares Alfrédo, Holzmuller Philippe, Gonzatti Marisa, Parra N.. 2018. Comparison of infectivity and virulence of clones of Trypanosoma evansi and Ttrypanosoma equiperdum Venezuelan strains in mice. Veterinary Parasitology, 253 : 60-64.
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Quartile : Q1, Sujet : VETERINARY SCIENCES / Quartile : Q2, Sujet : PARASITOLOGY
Résumé : Livestock trypanosomoses, caused by three species of the Trypanozoon subgenus, Trypanosoma brucei brucei, T. evansi and T. equiperdum are widely distributed and limit animal production throughout the world. The infectivity and virulence of clones derived from Trypanosoma evansi and Trypanosoma equiperdum Venezuelan strains were compared in an in vivo mouse model. Primary infectivity and virulence determinants such as survival rates, parasitemia levels, PCV, and changes in body weight and survival rates were monitored for up to 32 days. The T. equiperdum strain was the most virulent, with 100% mortality in mice, with the highest parasitemia levels (7.0 × 107 Tryps/ml) and loss of physical condition. The T. evansi strains induced 100% and 20% fatality in mice. Our results show that the homogeneous parasite populations maintain the virulent phenotype of the original T. equiperdum and T. evansi stocks. This is the first comparative study of infectivity and virulence determinants among clonal populations of T. equiperdum and T. evansi.
Mots-clés Agrovoc : Trypanosoma evansi, Trypanosoma equiperdum, infection expérimentale, virulence, clone, souris, bétail
Mots-clés géographiques Agrovoc : Venezuela (République bolivarienne du)
Classification Agris : L72 - Organismes nuisibles des animaux
Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes
Auteurs et affiliations
- Perrone Trina, IVIC (VEN)
- Aso Pedro Maria, Universidad Simón Bolívar (VEN)
- Mijares Alfrédo, IVIC (VEN)
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Holzmuller Philippe, CIRAD-BIOS-UMR ASTRE (FRA)
ORCID: 0000-0002-8919-9081
- Gonzatti Marisa, Universidad Simón Bolívar (VEN)
- Parra N., IVIC (VEN) - auteur correspondant
Source : Cirad-Agritrop (https://agritrop.cirad.fr/587466/)
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