Ayari-Fakhfakh Saïda Emna, Ghram Abdeljelil, Albina Emmanuel, Cetre-Sossah Catherine. 2018. Expression of cytokines following vaccination of goats with a recombinant capripoxvirus vaccine expressing Rift Valley fever virus proteins. Veterinary Immunology and Immunopathology, 197 : 15-20.
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Quartile : Q1, Sujet : VETERINARY SCIENCES / Quartile : Q4, Sujet : IMMUNOLOGY
Résumé : The mosquito-borne Rift Valley fever virus (RVFV) causes severe diseases in domesticated animals including cattle, sheep, camels and goats. Capripoxviruses (CPV) are suitable vectors for multivalent vaccine development. A recombinant rKS1-based CPV expressing the gene encoding the viral glycoprotein Gn of RVFV has been shown to induce protection in mice and sheep. The aim of this study was to evaluate the immunogenicity induced by this candidate vaccine in goats, and the level of cytokines produced by RVFV-specific Th1 and Th2 lymphocytes. The results of this study suggest that Th2 mediates immunity mainly through the significant production of IL4, which, coupled with a decrease in IFN-γ, may be involved in the replication of the capripoxvirus expressing the GN of RVFV. CD4+ cells may play the role of helper cells in B cell responses and neutralizing antibody production in the anti-CPV humoral response, leading to strong immunity against RVFV.
Mots-clés libres : Rift Valley fever, Immune response, Goats, Cytokines
Classification Agris : L73 - Maladies des animaux
Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes
Auteurs et affiliations
- Ayari-Fakhfakh Saïda Emna, Institut Pasteur de Tunis (TUN)
- Ghram Abdeljelil, Institut Pasteur de Tunis (TUN)
- Albina Emmanuel, CIRAD-BIOS-UMR ASTRE (GLP)
- Cetre-Sossah Catherine, CIRAD-BIOS-UMR ASTRE (REU) - auteur correspondant
Source : Cirad-Agritrop (https://agritrop.cirad.fr/588449/)
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