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Unleashing meiotic crossovers in crops

Mieulet Delphine, Aubert Grégoire, Bres Cécile, Klein Anthony, Droc Gaëtan, Vieille Emilie, Rond-Coissieux Céline, Sanchez Myriam, Dalmais Marion, Mauxion Jean-Philippe, Rothan Christophe, Guiderdoni Emmanuel, Mercier Raphael. 2018. Unleashing meiotic crossovers in crops. Nature Plants, 4 : pp. 1010-1016.

Journal article ; Article de recherche ; Article de revue à facteur d'impact
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Quartile : Outlier, Sujet : PLANT SCIENCES

Abstract : Improved plant varieties are important in our attempts to face the challenges of a growing human population and limited planet resources. Plant breeding relies on meiotic crossovers to combine favourable alleles into elite varieties1. However, meiotic crossovers are relatively rare, typically one to three per chromosome2, limiting the efficiency of the breeding process and related activities such as genetic mapping. Several genes that limit meiotic recombination were identified in the model species Arabidopsis thaliana2. Mutation of these genes in Arabidopsis induces a large increase in crossover frequency. However, it remained to be demonstrated whether crossovers could also be increased in crop species hybrids. We explored the effects of mutating the orthologues of FANCM3, RECQ44 or FIGL15 on recombination in three distant crop species, rice (Oryza sativa), pea (Pisum sativum) and tomato (Solanum lycopersicum). We found that the single recq4 mutation increases crossovers about three-fold in these crops, suggesting that manipulating RECQ4 may be a universal tool for increasing recombination in plants. Enhanced recombination could be used with other state-of-the-art technologies such as genomic selection, genome editing or speed breeding6 to enhance the pace and efficiency of plant improvement.

Mots-clés Agrovoc : riz, Hybridation, Croisement, sécurité alimentaire, Oryza, Variété

Mots-clés libres : Meiosis, Recombinaison, Rice, Crossovers

Classification Agris : F30 - Plant genetics and breeding
E50 - Rural sociology

Champ stratégique Cirad : Axe 1 (2014-2018) - Agriculture écologiquement intensive

Auteurs et affiliations

  • Mieulet Delphine, CIRAD-BIOS-UMR AGAP (FRA) ORCID: 0000-0001-6220-0372
  • Aubert Grégoire, INRA (FRA)
  • Bres Cécile, INRA (FRA)
  • Klein Anthony, INRA (FRA)
  • Droc Gaëtan, CIRAD-BIOS-UMR AGAP (FRA)
  • Vieille Emilie, INRA (FRA)
  • Rond-Coissieux Céline, INRA (FRA)
  • Sanchez Myriam, INRA (FRA)
  • Dalmais Marion, Institute of Plant Sciences (FRA)
  • Mauxion Jean-Philippe, INRA (FRA)
  • Rothan Christophe, INRA (FRA)
  • Guiderdoni Emmanuel, CIRAD-BIOS-UMR AGAP (FRA)
  • Mercier Raphael, Institut Jean-Pierre Bourgin (FRA) - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/589622/)

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