A genomic map of climate adaptation in Mediterranean cattle breeds

Flori Laurence, Moazami Goudarzi Katayoun, Alary Véronique, Araba Abdelillah, Boujenane Ismail, Boushaba Nadjet, Casabianca François, Casu Sara, Ciampolini Roberta, Coeur d'Acier Armelle, Coquelle Corinne, Delgado Juan-Vicente, El Beltagy Ahmed, Hadjipavlou Georgia, Jousselin Emmanuelle, Landi Vincenzo, Lauvie Anne, Lecomte Philippe, Ligda Christina, Marinthe Caroline, Martinez Amparo, Mastrangelo Salvatore, Menni Dalal, Moulin Charles-Henri, Osman Mona-Abdelzaher, Pineau Olivier, Portolano Baldassare, Rodellar Clementina, Saïdi-Mehtar Nadhira, Sechi Tiziana, Sempere Guilhem, Thevenon Sophie, Tsiokos Dimitrios, Laloë Denis, Gautier Mathieu. 2019. A genomic map of climate adaptation in Mediterranean cattle breeds. Molecular Ecology, 28 (5) : 1009-1029.

Quartile : Q1, Sujet : ECOLOGY / Quartile : Q1, Sujet : EVOLUTIONARY BIOLOGY / Quartile : Q1, Sujet : BIOCHEMISTRY & MOLECULAR BIOLOGY

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Résumé : Domestic species such as cattle (Bos taurus taurus and B. t. indicus) represent attractive biological models to characterize the genetic basis of short‐term evolutionary response to climate pressure induced by their post‐domestication history. Here, using newly generated dense SNP genotyping data, we assessed the structuring of genetic diversity of 21 autochtonous cattle breeds from the whole Mediterranean basin and performed genome‐wide association analyses with covariables discriminating the different Mediterranean climate subtypes. This provided insights into both the demographic and adaptive histories of Mediterranean cattle. In particular, a detailed functional annotation of genes surrounding variants associated with climate variations highlighted several biological functions involved in Mediterranean climate adaptation such as thermotolerance, UV protection, pathogen resistance or metabolism with strong candidate genes identified (e.g., NDUFB3, FBN1, METTL3, LEF1, ANTXR2 and TCF7). Accordingly, our results suggest that main selective pressures affecting cattle in Mediterranean area may have been related to variation in heat and UV exposure, in food resources availability and in exposure to pathogens, such as anthrax bacteria (Bacillus anthracis). Furthermore, the observed contribution of the three main bovine ancestries (indicine, European and African taurine) in these different populations suggested that adaptation to local climate conditions may have either relied on standing genomic variation of taurine origin, or adaptive introgression from indicine origin, depending on the local breed origins. Taken together, our results highlight the genetic uniqueness of local Mediterranean cattle breeds and strongly support conservation of these populations.

Mots-clés Agrovoc : bétail, race (animal), génotype, climat méditerranéen, facteur climatique, adaptation, polymorphisme génétique, carte génétique

Mots-clés géographiques Agrovoc : France, Italie, Espagne, Algérie, Maroc, Türkiye, Grèce, Chypre, Égypte

Mots-clés libres : Cattle, Climate, Genetics, Local adaptation, SNP, Mediterranean

Classification Agris : L10 - Génétique et amélioration des animaux
P40 - Météorologie et climatologie

Champ stratégique Cirad : CTS 6 (2019-) - Changement climatique

Auteurs et affiliations

• Flori Laurence, INRA (FRA) - auteur correspondant
• Moazami Goudarzi Katayoun, INRA (FRA)
• Alary Véronique, CIRAD-ES-UMR SELMET (MAR) ORCID: 0000-0003-4844-5423
• Araba Abdelillah, IAV Hassan II (MAR)
• Boujenane Ismail, IAV Hassan II (MAR)
• Boushaba Nadjet, Université d'Oran (DZA)
• Casabianca François, INRA (FRA)
• Casu Sara, Agris sardegna (ITA)
• Ciampolini Roberta, Dipartimento di scienze veterinarie (ITA)
• Coeur d'Acier Armelle, INRA (FRA)
• Coquelle Corinne
• Delgado Juan-Vicente, Laboratorio de Genetica Molecular Aplicada (ESP)
• El Beltagy Ahmed, APRI (EGY)
• Hadjipavlou Georgia, Agricultural Research Institute (CYP)
• Jousselin Emmanuelle, INRA (FRA)
• Landi Vincenzo, Laboratorio de Genetica Molecular Aplicada (ESP)
• Lauvie Anne, INRA (FRA)
• Lecomte Philippe, INRA (FRA) ORCID: 0000-0003-1040-7886
• Ligda Christina, NAGREF (GRC)
• Marinthe Caroline
• Martinez Amparo, Laboratorio de Genetica Molecular Aplicada (ESP)
• Mastrangelo Salvatore, Università degli studi di Palermo (ITA)
• Menni Dalal, IAV Hassan II (MAR)
• Moulin Charles-Henri, INRA (FRA)
• Osman Mona-Abdelzaher, APRI (EGY)
• Pineau Olivier, La Tour du Valat, Centre de recherche pour la conservation des zones humides méditerranéennes (FRA)
• Portolano Baldassare, Università degli studi di Palermo (ITA)
• Rodellar Clementina, Universidad de Zaragoza (ESP)
• Saïdi-Mehtar Nadhira, Université d'Oran (DZA)
• Sechi Tiziana, Agris‐Sardegna Servizio Ricerca per la Zootecnica (ITA)
• Sempere Guilhem, CIRAD-BIOS-UMR INTERTRYP (FRA) ORCID: 0000-0001-7429-2091
• Thevenon Sophie, CIRAD-BIOS-UMR INTERTRYP (FRA) ORCID: 0000-0001-6059-5884
• Tsiokos Dimitrios, Research Institute for Animal Science (GRC)
• Laloë Denis, INRA (FRA)
• Gautier Mathieu, INRA (FRA)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/591860/)

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