Spatial assessment of contact between humans and Anopheles and Aedes mosquitoes in a medium-sizedAafrican urban setting, using salivary antibody–based biomarkers

Sagna André B., Kassie Daouda, Couvray Agnès, Adja Akré Maurice, Hermann Emmanuel, Riveau Gilles, Salem Gérard, Fournet Florence, Remoue Franck. 2019. Spatial assessment of contact between humans and Anopheles and Aedes mosquitoes in a medium-sizedAafrican urban setting, using salivary antibody–based biomarkers. Journal of Infectious Diseases, 220 (7) : 1199-1208.

https://doi.org/10.1093/infdis/jiz289

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Quartile : Q1, Sujet : INFECTIOUS DISEASES / Quartile : Q1, Sujet : MICROBIOLOGY / Quartile : Q1, Sujet : IMMUNOLOGY

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Résumé : Background: Anarchic and poorly controlled urbanization led to an increased risk of mosquito-borne diseases (MBD) in many African cities. Here, we evaluate the spatial heterogeneity of human exposure to malaria and arboviral disease vectors in an urban area of northern Senegal, using antibody-based biomarkers of exposure to Anopheles and Aedes mosquito bites. Methods: A cross-sectional study was undertaken during the rainy season of 2014 in 4 neighborhoods of Saint-Louis, a city in northern Senegal. Among children aged 6–59 months in each neighborhood, the dried blood spot technique was used to evaluate immunoglobulin G (IgG) responses to both gSG6-P1 (Anopheles) and Nterm–34-kDa (Aedes) salivary peptides as validated biomarkers of respective mosquito bite exposure. Results: IgG response levels to gSG6-P1 and Nterm–34-kDa salivary peptides varied significantly between the 4 neighborhoods (P < .0001). The level of exposure to Aedes bites also varied according to household access to sanitation services (P = .027), whereas that of exposure to Anopheles bites varied according to insecticide-treated bed net use (P = .006). In addition, spatial clusters of high contact between humans and mosquitoes were identified inside 3 neighborhoods. Conclusions: Antibody-based biomarkers of exposure to Anopheles and Aedes mosquito bites could be helpful tools for evaluating the heterogeneity of exposure to malaria and arboviral disease vectors by national control programs.

Mots-clés Agrovoc : Anopheles, Aedes, Culicidae, maladie transmise par vecteur, malaria, urbanisation, arbovirus, marqueur génétique

Mots-clés géographiques Agrovoc : Sénégal

Mots-clés libres : Urban areas, Salivary biomarkers, GSG6-P1, Anopheles, Nterm-34kDa, Aedes, MBD risk

Classification Agris : S50 - Santé humaine
L20 - Écologie animale

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

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