Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood

Sanchez-Cardenas Claudia, Fontanaud Pierre, He Zhenhe, Lafont Chrystel, Meunier Anne Cecile, Schaeffer Marie, Carmignac Danielle, Molino François, Coutry Nathalie, Bonnefont Xavier, Gouty-Colomer Laurie-Anne, Gavois Elodie, Hodson David J., Le Tissier Paul, Robinson Ian C.A.F., Mollard Patrice. 2010. Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood. Proceedings of the National Academy of Sciences of the United States of America, 107 (50) : 21878-21883.

Quartile : Outlier, Sujet : MULTIDISCIPLINARY SCIENCES

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Economie-gestion; Psychologie-éthologie-ergonomie

Résumé : There are well-recognized sex differences in many pituitary endocrine axes, usually thought to be generated by gonadal steroid imprinting of the neuroendocrine hypothalamus. However, the recognition that growth hormone (GH) cells are arranged in functionally organized networks raises the possibility that the responses of the network are different in males and females. We studied this by directly monitoring the calcium responses to an identical GH-releasing hormone (GHRH) stimulus in populations of individual GH cells in slices taken from male and female murine GH-eGFP pituitary glands. We found that the GH cell network responses are sexually dimorphic, with a higher proportion of responding cells in males than in females, correlated with greater GH release from male slices. Repetitive waves of calcium spiking activity were triggered by GHRH in some males, but were never observed in females. This was not due to a permanent difference in the network architecture between male and female mice; rather, the sex difference in the proportions of GH cells responding to GHRH were switched by postpubertal gonadectomy and reversed with hormone replacements, suggesting that the network responses are dynamically regulated in adulthood by gonadal steroids. Thus, the pituitary gland contributes to the sexually dimorphic patterns of GH secretion that play an important role in differences in growth and metabolism between the sexes.

Mots-clés Agrovoc : biologie animale, physiologie animale, physiologie du développement, hypophyse, dimorphisme sexuel, hormone sexuelle, hormone stéroïdique, stéroïde, adulte

Mots-clés libres : Sex hormones, Body growth, Calcium signaling, Systems biology

Classification Agris : L50 - Physiologie et biochimie animales

Champ stratégique Cirad : Axe 2 (2014-2018) - Valorisation de la biomasse

Auteurs et affiliations

• Sanchez-Cardenas Claudia, Institute of Functional Genomics (FRA)
• Fontanaud Pierre, Institute of Functional Genomics (FRA)
• He Zhenhe, MRC (GBR)
• Lafont Chrystel, Institute of Functional Genomics (FRA)
• Meunier Anne Cecile, CNRS (FRA)
• Schaeffer Marie, Institute of Functional Genomics (FRA)
• Carmignac Danielle, MRC (GBR)
• Molino François, Institute of Functional Genomics (FRA)
• Coutry Nathalie, Institute of Functional Genomics (FRA)
• Bonnefont Xavier, Institute of Functional Genomics (FRA)
• Gouty-Colomer Laurie-Anne, Institute of Functional Genomics (FRA)
• Gavois Elodie, Institut Fédératif de Recherches 3 (FRA)
• Hodson David J., Institute of Functional Genomics (FRA)
• Le Tissier Paul, MRC (GBR)
• Robinson Ian C.A.F., MRC (GBR)
• Mollard Patrice, Institute of Functional Genomics (FRA) - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/595664/)

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