Contagious Bovine and Caprine Pleuropneumonia: A research community's recommendations for the development of better vaccines

Jores Joerg, Baldwin Cynthia, Blanchard Alain, Browning Glenn, Colston Angie, Gerdts Volker, Goovaerts Danny, Heller Martin, Juleff Nick, Labroussaa Fabien, Liljander Anne, Muuka Geoffrey, Nene Vish, Nir-Paz Ran, Sacchini Flavio, Summerfield Artur, Thiaucourt François, Unger Hermann, Vashee Sanjay, Wang Xiumei, Salt Jeremy. 2020. Contagious Bovine and Caprine Pleuropneumonia: A research community's recommendations for the development of better vaccines. Npj Vaccines, 5:66, 9 p.

https://doi.org/10.1038/s41541-020-00214-2

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Quartile : Q1, Sujet : IMMUNOLOGY / Quartile : Q1, Sujet : MEDICINE, RESEARCH & EXPERIMENTAL

Résumé : Contagious bovine pleuropneumonia (CBPP) and contagious caprine pleuropneumonia (CCPP) are major infectious diseases of ruminants caused by mycoplasmas in Africa and Asia. In contrast with the limited pathology in the respiratory tract of humans infected with mycoplasmas, CBPP and CCPP are devastating diseases associated with high morbidity and mortality. Beyond their obvious impact on animal health, CBPP and CCPP negatively impact the livelihood and wellbeing of a substantial proportion of livestock-dependent people affecting their culture, economy, trade and nutrition. The causative agents of CBPP and CCPP are Mycoplasma mycoides subspecies mycoides and Mycoplasma capricolum subspecies capripneumoniae, respectively, which have been eradicated in most of the developed world. The current vaccines used for disease control consist of a live attenuated CBPP vaccine and a bacterin vaccine for CCPP, which were developed in the 1960s and 1980s, respectively. Both of these vaccines have many limitations, so better vaccines are urgently needed to improve disease control. In this article the research community prioritized biomedical research needs related to challenge models, rational vaccine design and protective immune responses. Therefore, we scrutinized the current vaccines as well as the challenge-, pathogenicity- and immunity models. We highlight research gaps and provide recommendations towards developing safer and more efficacious vaccines against CBPP and CCPP.

Mots-clés Agrovoc : maladie des animaux, maladie infectieuse, vaccin, pleuropneumonie, péripneumonie contagieuse bovine, pleuropneumonie contagieuse caprine, Mycoplasma, Mycoplasma capricolum, Mycoplasma mycoides, santé animale

Mots-clés libres : Bacterial infection, Vaccines

Classification Agris : L73 - Maladies des animaux
L70 - Sciences et hygiène vétérinaires - Considérations générales

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

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