Search for selection signatures related to trypanosomosis tolerance in African goats

Serranito Bruno, Taurisson-Mouret Dominique, Harkat Sahraoui, Laoun Abbas, Ouchene-Khelifi Nadjet-Amina, Pompanon François, Benjelloun Badr, Cecchi Giuliano, Thevenon Sophie, Lenstra Johannes A., Da Silva Anne. 2021. Search for selection signatures related to trypanosomosis tolerance in African goats. Frontiers in Genetics, 12:715732, 15 p.

Quartile : Q1, Sujet : GENETICS & HEREDITY

Résumé : Livestock is heavily affected by trypanosomosis in Africa. Through strong selective pressure, several African indigenous breeds of cattle and small ruminants have acquired varying degrees of tolerance against this disease. In this study, we combined LFMM and PCAdapt for analyzing two datasets of goats from West-Central Africa and East Africa, respectively, both comprising breeds with different assumed levels of trypanotolerance. The objectives were (i) to identify molecular signatures of selection related to trypanotolerance; and (ii) to guide an optimal sampling for subsequent studies. From 33 identified signatures, 18 had been detected previously in the literature as being mainly associated with climatic adaptations. The most plausible signatures of trypanotolerance indicate the genes DIS3L2, COPS7B, PD5A, UBE2K, and UBR1. The last gene is of particular interest since previous literature has already identified E3-ubiquitin ligases as playing a decisive role in the immune response. For following-up on these findings, the West-Central African area appears particularly relevant because of (i) a clear parasitic load gradient related to a humidity gradient, and (ii) still restricted admixture levels between goat breeds. This study illustrates the importance of protecting local breeds, which have retained unique allelic combinations conferring their remarkable adaptations.

Mots-clés Agrovoc : trypanosomose, tolérance, caprin, résistance aux maladies, maladie des animaux

Mots-clés géographiques Agrovoc : Burkina Faso, Cameroun, Mali, Nigéria, Burundi, Kenya, République-Unie de Tanzanie, Ouganda

Mots-clés complémentaires : signatures de sélection

Mots-clés libres : Trypanosomosis, Trypanotolerance, Goats, Local adaptation, Selection signatures

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Auteurs et affiliations

• Serranito Bruno, MHN (FRA)
• Taurisson-Mouret Dominique, Université de Limoges (FRA)
• Harkat Sahraoui, Faculté agro-vétérinaire universitaire de Blida (DZA)
• Laoun Abbas, University of Djelfa (DZA)
• Ouchene-Khelifi Nadjet-Amina, Faculté agro-vétérinaire universitaire de Blida (DZA)
• Pompanon François, Université de Grenoble (FRA)
• Benjelloun Badr, INRA [Maroc] (MAR)
• Cecchi Giuliano, FAO (ITA)
• Thevenon Sophie, CIRAD-BIOS-UMR INTERTRYP (FRA) ORCID: 0000-0001-6059-5884
• Lenstra Johannes A., Utrecht University (NLD)
• Da Silva Anne, Université de Limoges (FRA) - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/599022/)

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