Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle

Lutje Vittoria, Mertens Bea, Boulangé Alain, Williams D.J.L., Authié Edith. 1995. Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle. Experimental Parasitology, 81 (2) : 154-164.

Résumé : T-cell-mediated immune responses to defined antigens of Trypanosoma congolense were measured in cattle undergoing primary infection. The antigens used were the variable surface glycoprotein and two invariant antigens, a 33-kDa cysteine protease (congopain) and a recombinant form of a 69-kDa heat-shock protein. Proliferative responses were highest during the second week postinfection and were detected in cells obtained from the lymph node draining the site of infection but not in peripheral blood mononuclear cells. Production of IL-2 and IFN-γ was measured in supernatants from antigen-stimulated lymph node cell cultures. Expression of IL-2, IL-4, and IFN-γ mRNA was detected in antigen-stimulated lymph node cells by reverse transcription-polymerase chain amplification.

Mots-clés Agrovoc : interleukine, Trypanosoma congolense, ganglion lymphatique, santé animale, réponse immunitaire, parasitologie, bétail

Classification Agris : L73 - Maladies des animaux
L72 - Organismes nuisibles des animaux
L50 - Physiologie et biochimie animales

Auteurs et affiliations

• Lutje Vittoria, ILRI (KEN) - auteur correspondant
• Mertens Bea, ILRI (KEN) - auteur correspondant
• Boulangé Alain, ILRI (KEN) ORCID: 0000-0002-8505-7465
• Williams D.J.L., ILRI (KEN)
• Authié Edith, ILRI (KEN)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/603020/)

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