Exploring alternative insecticide delivery options in a "lethal house lure" for malaria vector control

Oumbouke Welbeck A., Barreaux Antoine, Zran Innocent T., Koffi Alphonsine A., N’Guessan Yao, Ahoua Alou Ludovic P., Wolie Rosine Z., Cook Jackie, Sternberg Eleanore D., Thomas Matthew B., N'Guessan Raphaël. 2023. Exploring alternative insecticide delivery options in a "lethal house lure" for malaria vector control. Scientific Reports, 13:4820, 11 p.

https://doi.org/10.1038/s41598-023-31116-7

Article de revue ; Article de recherche ; Article de revue à facteur d'impact Revue en libre accès total

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Résumé : The In2Care EaveTube is a house modification designed to block and kill malaria mosquitoes using an electrostatic netting treated with insecticide powder. A previous study demonstrated prolonged duration of effective action of insecticide-treated electrostatic netting in a semi-field setting. As part of a cluster randomized controlled trial (CRT) of the EaveTube intervention in Côte d'Ivoire, we investigated the residual efficacy of a pyrethroid insecticide deployed in EaveTubes under village conditions of use. We also explored the scope of using existing malaria control technologies including LLINs and IRS as alternative methods to deliver insecticides in the lethal house lure. The efficacy of beta-cyfluthrin was monitored over time using the “eave tube bioassay” method. Mortality of beta-cyfluthrin exposed pyrethroid resistant Anopheles gambiae mosquitoes was > 80% after 4 months. The impact (mosquito mortality) of PVC tubes coated with pirimiphos methyl was similar to that of beta-cyfluthrin treated insert (66.8 vs. 62.8%) in release-recapture experiments in experimental huts. Efficacy was significantly lower with all the LLINs tested; however, the roof of PermaNet 3.0 induced significantly higher mosquito mortality (50.4%) compared to Olyset Plus (25.9%) and Interceptor G2 (21.6%) LLINs. The efficacy of the alternative delivery methods was short-lived with mortality decreasing below 50% within 2 months in residual activity bioassays. None of the products tested appeared superior to the powder treatments. Further research is therefore required to identify suitable insecticide delivery options in EaveTube for malaria vector control.

Mots-clés Agrovoc : malaria, pyrimiphos méthyl, Anopheles gambiae, insecticide, vecteur de maladie, modèle mathématique, contrôle de maladies, méthode de lutte

Mots-clés géographiques Agrovoc : Côte d'Ivoire

Mots-clés libres : Vector control, Malaria, Mosquito, Innovation, Lethal house lure

Classification Agris : L72 - Organismes nuisibles des animaux
L73 - Maladies des animaux
S50 - Santé humaine

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Agences de financement hors UE : Bill and Melinda Gates Foundation

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