Unravelling the origin of SARS-CoV-2: is the model good?

Frutos Roger, Gavotte Laurent, Devaux Christian A.. 2021. Unravelling the origin of SARS-CoV-2: is the model good?. New Microbes and New Infections, 43:100918, 3 p.

https://doi.org/10.1016/j.nmni.2021.100918

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Résumé : MacLean and colleagues recently published a very elegant analysis demonstrating that SARS-CoV-2 carries signs of positive selection and that it was already adapted to humans prior to the emergence of COVID-19. Using the Spillover theory as a reference model for zoonotic emergence, they conclude that SARS-CoV-2 must have acquired this human adaptation in bats. We reinterpreted the data from MacLean et al. using a different model of zoonotic emergence as reference, the Circulation model. The use of the Circulation model provides a more parsimonious interpretation showing that this adaptation to humans occurs in the human population after primo infection.

Mots-clés Agrovoc : coronavirus 2 du syndrome respiratoire aigu sévère, covid-19, Chiroptera, zoonose, transmission des maladies, modélisation, genre humain

Mots-clés libres : COVID-19, Circulation model, Emergence, Evolution in humans, SARS-COV-2

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