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Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model

Frutos Roger, Gavotte Laurent, Devaux Christian A.. 2021. Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model. Infection, Genetics and Evolution, 95:104812, 9 p.

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Quartile : Q2, Sujet : INFECTIOUS DISEASES

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Anthropologie-Ethnologie

Résumé : While the COVID-19 pandemic continues to spread with currently more than 117 million cumulated cases and 2.6 million deaths worldwide as per March 2021, its origin is still debated. Although several hypotheses have been proposed, there is still no clear explanation about how its causative agent, SARS-CoV-2, emerged in human populations. Today, scientifically-valid facts that deserve to be debated still coexist with unverified statements blurring thus the knowledge on the origin of COVID-19. Our retrospective analysis of scientific data supports the hypothesis that SARS-CoV-2 is indeed a naturally occurring virus. However, the spillover model considered today as the main explanation to zoonotic emergence does not match the virus dynamics and somehow misguided the way researches were conducted. We conclude this review by proposing a change of paradigm and model and introduce the circulation model for explaining the various aspects of the dynamic of SARS-CoV-2 emergence in humans.

Mots-clés Agrovoc : covid-19, pandémie, coronavirus 2 du syndrome respiratoire aigu sévère, provenance, transmission des maladies, modélisation

Mots-clés libres : COVID-19, SARS-COV-2, Origin, Transmission, Zoonotic emergence, Spillover model, Circulation mode

Agences de financement hors UE : Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Université de Montpellier, Centre National de la Recherche Scientifique

Auteurs et affiliations

  • Frutos Roger, CIRAD-BIOS-UMR TRYPANOSOMES (FRA) - auteur correspondant
  • Gavotte Laurent, Université de Montpellier (FRA)
  • Devaux Christian A., CNRS (FRA)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/605907/)

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