A theoretical model for host-controlled regulation of symbiont density

Whittle Mathilda, Bonsall Michael B., Barreaux Antoine, Ponton Fleur, English Sinead. 2023. A theoretical model for host-controlled regulation of symbiont density. Journal of Evolutionary Biology, 36 (12), n.spéc. The Evolutionary Significance of Animal Microbiomes : 1731-1744.

Url - jeu de données - Entrepôt autre : https://doi.org/10.5061/dryad.xgxd254nh

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Résumé : There is growing empirical evidence that animal hosts actively control the density of their mutualistic symbionts according to their requirements. Such active regulation can be facilitated by compartmentalization of symbionts within host tissues, which confers a high degree of control of the symbiosis to the host. Here, we build a general theoretical framework to predict the underlying ecological drivers and evolutionary consequences of host-controlled endosymbiont density regulation for a mutually obligate association between a host and a compartmentalized, vertically transmitted symbiont. Building on the assumption that the costs and benefits of hosting a symbiont population increase with symbiont density, we use state-dependent dynamic programming to determine an optimal strategy for the host, i.e., that which maximizes host fitness, when regulating the density of symbionts. Simulations of active host-controlled regulation governed by the optimal strategy predict that the density of the symbiont should converge to a constant level during host development, and following perturbation. However, a similar trend also emerges from alternative strategies of symbiont regulation. The strategy which maximizes host fitness also promotes symbiont fitness compared to alternative strategies, suggesting that active host-controlled regulation of symbiont density could be adaptive for the symbiont as well as the host. Adaptation of the framework allowed the dynamics of symbiont density to be predicted for other host-symbiont ecologies, such as for non-essential symbionts, demonstrating the versatility of this modelling approach.

Mots-clés Agrovoc : modèle mathématique, symbiose, symbiote, dynamique des populations, hôte

Mots-clés libres : Optimization, Symbiosis, Fitness, Energy allocation, Cost-benefit

Classification Agris : L72 - Organismes nuisibles des animaux
U10 - Informatique, mathématiques et statistiques

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Auteurs et affiliations

• Whittle Mathilda, University of Bristol (GBR) - auteur correspondant
• Bonsall Michael B., University of Oxford (GBR)
• Barreaux Antoine, CIRAD-BIOS-UMR INTERTRYP (FRA) ORCID: 0000-0001-5822-761X
• Ponton Fleur, University of Sydney (AUS)
• English Sinead, University of Bristol (GBR)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/607757/)

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