Immune response in cattle trypanosomosis and trypanotolerance: Main findings and gaps

Gnohion Fabrice Somé, Sere Modou, Somda Martin Bienvenu, Dayo Guiguigbaza-Kossigan, Ouédraogo Georges Anicet, Boulangé Alain, Maarifi Ghizlane, Chantal Isabelle, Berthier Teyssedre David, Thévenon Sophie. 2024. Immune response in cattle trypanosomosis and trypanotolerance: Main findings and gaps. Parasite Immunology, 46 (11):e13075, 12 p.

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Résumé : Trypanosome parasites of the genus Trypanosoma cause African animal trypanosomosis, a devastating livestock disease plagu- ing sub-Saharan Africa. Unlike many protozoan parasites, these extracellular blood-borne pathogens directly engage the host's immune system. While the mouse model has provided valuable insights, a comprehensive understanding of the bovine immune response to trypanosomes remains elusive. Addressing the immune response in cattle, the most relevant host species, and how it takes part in mitigating the negative impact of the disease could contribute to setting up sustainable control strategies. This review summarises the current knowledge of the immune response in cattle during trypanosomosis. Following a brief overview of infection processes and bovine trypanotolerance, we present advances in the regulation of host innate, inflammatory and adaptive responses and delve into the key immunological players involved in immunoactivities and immunosuppression. We discuss how these mechanisms contribute to tolerance or susceptibility to infection, highlighting critical gaps in knowledge that require further investigation.

Mots-clés Agrovoc : trypanosomose, immunologie, relation hôte pathogène, bovin, résistance aux maladies, réponse immunitaire, Trypanosoma, immunité, trypanosomose africaine, contrôle de maladies, transmission des maladies, maladie des animaux, Stomoxys, épidémiologie, immunodépression, trypanotolérance

Mots-clés libres : Antibodies, Cattle, Trypanosomosis, Trypanotolerance, Cytokines, Immune response

Classification Agris : L72 - Organismes nuisibles des animaux
L70 - Sciences et hygiène vétérinaires - Considérations générales

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Agences de financement européennes : European Commission

Programme de financement européen : H2020

Projets sur financement : (EU) COntrolling and progressively Minimizing the Burden of Animal Trypanosomosis

Auteurs et affiliations

• Gnohion Fabrice Somé, CIRDES (BFA)
• Sere Modou, CIRDES (BFA)
• Somda Martin Bienvenu, CIRDES (BFA)
• Dayo Guiguigbaza-Kossigan, CIRDES (BFA)
• Ouédraogo Georges Anicet, Université Nazi Boni (BFA)
• Boulangé Alain, CIRAD-BIOS-UMR INTERTRYP (CIV) ORCID: 0000-0002-8505-7465
• Maarifi Ghizlane, CIRAD-BIOS-UMR INTERTRYP (FRA) ORCID: 0000-0002-7974-3821
• Chantal Isabelle, CIRAD-BIOS-UMR INTERTRYP (FRA) ORCID: 0000-0002-3429-484X
• Berthier Teyssedre David, CIRAD-BIOS-UMR INTERTRYP (FRA) ORCID: 0000-0002-3283-6588
• Thévenon Sophie, CIRAD-BIOS-UMR INTERTRYP (FRA) ORCID: 0000-0001-6059-5884 - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/610972/)

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