Evidence for circulation of Rift Valley fever virus in wildlife and domestic animals in a forest environment in Gabon, Central Africa

Becquart Pierre, Bohou Kombila Linda, Mebaley Telsta Ndong, Paupy Christophe, Garcia Déborah, Nesi Nicolas, Olive Marie-Marie, Vanhomwegen Jessica, Boundenga Larson, Mombo Illich Manfred, Piro-Megy Camille, Fritz Matthieu, Lenguiya Léadisaelle Hosanna, Ar Gouilh Meriadeg, Leroy Eric M., N'Dilimabaka Nadine, Cetre-Sossah Catherine, Maganga Gaël Darren. 2024. Evidence for circulation of Rift Valley fever virus in wildlife and domestic animals in a forest environment in Gabon, Central Africa. PLoS Neglected Tropical Diseases, 18 (3):e0011756, 15 p.

Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/nuccore/OR528950 / Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/nuccore/OR528951 / Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/nuccore/OR528952 / Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/nuccore/OR528953

Résumé : Rift Valley fever (RVF) is a mosquito-borne viral zoonosis caused by the Rift Valley fever virus (RVFV) that can infect domestic and wild animals. Although the RVFV transmission cycle has been well documented across Africa in savanna ecosystems, little is known about its transmission in tropical rainforest settings, particularly in Central Africa. We therefore conducted a survey in northeastern Gabon to assess RVFV circulation among wild and domestic animals. Among 163 wildlife samples tested using RVFV-specific RT-qPCR, four ruminants belonging to subfamily Cephalophinae were detected positive. The phylogenetic analysis revealed that the four RVFV sequences clustered together with a virus isolated in Namibia within the well-structured Egyptian clade. A cross-sectional survey conducted on sheep, goats and dogs living in villages within the same area determined the IgG RVFV-specific antibody prevalence using cELISA. Out of the 306 small ruminants tested (214 goats, 92 sheep), an overall antibody prevalence of 15.4% (95% CI [11.5–19.9]) was observed with a higher rate in goats than in sheep (20.1% versus 3.3%). RVFV-specific antibodies were detected in a single dog out of the 26 tested. Neither age, sex of domestic animals nor season was found to be significant risk factors of RVFV occurrence. Our findings highlight sylvatic circulation of RVFV for the first time in Gabon. These results stress the need to develop adequate surveillance plan measures to better control the public health threat of RVFV.

Mots-clés Agrovoc : Virus de la fièvre de la vallée du Rift, fièvre de la Vallée du Rift, animal sauvage, épidémiologie, forêt tropicale humide, surveillance épidémiologique, transmission des maladies, ruminant, animal domestique, caprin, vecteur de maladie, zoonose, sérologie

Mots-clés géographiques Agrovoc : Gabon, Afrique centrale

Mots-clés libres : Rift Valley fever virus, Domestic animals, Wildlife, Goats, Sheep, Mosquitoes, Ruminants, Gabon

Auteurs et affiliations

• Becquart Pierre, IRD (FRA) - auteur correspondant
• Bohou Kombila Linda, Centre Interdisciplinaire de Recherches Médicales de Franceville (GAB)
• Mebaley Telsta Ndong, CIRMF (GAB)
• Paupy Christophe, IRD (CMR)
• Garcia Déborah, IRD (FRA)
• Nesi Nicolas, UNICAEN (FRA)
• Olive Marie-Marie, CIRAD-BIOS-UMR ASTRE (FRA)
• Vanhomwegen Jessica, Institut Pasteur (FRA)
• Boundenga Larson, Centre Interdisciplinaire de Recherches Médicales de Franceville (GAB)
• Mombo Illich Manfred, Centre Interdisciplinaire de Recherches Médicales de Franceville (GAB)
• Piro-Megy Camille, CIRAD-BIOS-UMR ASTRE (FRA) ORCID: 0009-0007-1275-2612
• Fritz Matthieu, IRD (FRA)
• Lenguiya Léadisaelle Hosanna, UMNG (COG)
• Ar Gouilh Meriadeg, INSERM (FRA)
• Leroy Eric M., IRD (FRA)
• N'Dilimabaka Nadine, CIRMF (GAB)
• Cetre-Sossah Catherine, CIRAD-BIOS-UMR ASTRE (FRA)
• Maganga Gaël Darren, CIRMF (FRA)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/611330/)

Métriques

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