Modeling the dynamic of multiwave diseases: the model of hand, foot and mouth disease

Ravel Patrice, Duy Nghia Ngu, Kister Guilhem, Huong Le Thi Song, Dwivedi Ankit, Devaux Christian A., Duong Tran Nhu, Hien Nguyen Tran, Gavotte Laurent, Cornillot Emmanuel, Frutos Roger. 2024. Modeling the dynamic of multiwave diseases: the model of hand, foot and mouth disease. Viruses, 16 (8), n.spéc. Advanced Strategies against SARS-CoV-2 Variants and Future Emerging Virus Outbreaks:1217, 11 p.

Résumé : An HFMD outbreak spread over the city of Hải Phòng from summer 2011 to autumn 2012. This epidemic was chosen because it was the very first HFMD epidemic in North Vietnam, eliminating thus interferences with previous outbreaks. This epidemic displayed three separate waves. A complete dataset was collected for more than 9500 patients during this period, which enabled us to analyze this epidemic at different scales. Access to the healthcare system was crucial during this period, which was possible due to a reorganization of the system in February–March 2012. An analysis at the commune level enabled us to track the epidemic along certain communication routes. The three-waves structure reveals a wide disparity at the district level. We developed a mathematical model showing high accuracy at the adjustment of data for both the total number of cases and for the number of cases per week. As a consequence, the model was able to accurately determine the dates of the beginning and end of each wave and to show that they overlapped. Using mathematical functions associated with this model, it was possible to calculate the probability for a patient to belong to a specific wave.

Mots-clés Agrovoc : épidémiologie, modèle mathématique, surveillance épidémiologique, santé humaine, épidémie, modélisation, transmission des maladies, virologie, maladie de l'homme

Mots-clés géographiques Agrovoc : Viet Nam

Mots-clés complémentaires : Syndrome pieds-mains-bouche (HFMD)

Mots-clés libres : Virologie, HFMD, Multiwave diseases, Modeling

Classification Agris : S50 - Santé humaine

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Auteurs et affiliations

• Ravel Patrice, Institut de Recherche en Cancérologie de Montpellier (FRA) - auteur correspondant
• Duy Nghia Ngu, NIHE (VNM)
• Kister Guilhem, UM2 (FRA)
• Huong Le Thi Song, Hai Phong Preventive Medicine Center (VNM)
• Dwivedi Ankit, Institut de Recherche en Cancérologie de Montpellier (FRA)
• Devaux Christian A., IHU Méditerranée Infection (FRA)
• Duong Tran Nhu, NIHE (VNM)
• Hien Nguyen Tran, NIHE (VNM)
• Gavotte Laurent, Université de Montpellier (FRA)
• Cornillot Emmanuel, Institut de Recherche en Cancérologie de Montpellier (FRA)
• Frutos Roger, CIRAD-BIOS-UMR INTERTRYP (FRA) - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/612128/)

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