Parathyroid hormone-related peptide stimulates intestinal strontium absorption in Camels (Camelus dromedarius)

El Khasmi Mohammed, Riad Fouad, Safwate Abdallah, Farh Mohamed, El Abbadi Najia, Davicco Marie Jeanne, Coxam Véronique, Faye Bernard. 2008. Parathyroid hormone-related peptide stimulates intestinal strontium absorption in Camels (Camelus dromedarius). Journal of Camelid Science, 1 : 18-23. International Conference of the Society of Camelids Research and Development, Al-Ain, Émirats arabes unis, 15 Avril 2006/17 Avril 2006.

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Résumé : The present work was undertaken to evaluate the stimulatory effect of Parathyroid hormone-related peptide (PTHrP) on the intestinal calcium (Ca) absorption using stable strontium (Sr) as a surgoate marker in 10 Camels. The animals were randomly divided into two groups of five animals. Just after an oral Sr load (4.1 mmol of SrCl2), the first and the second (control) groups received either an i.v infusion of synthetic human PTHrP or solvent alone respectively. PTHrP induced a significant rise in levels of plasma Sr (52.8 ± 4.6 [mu]mol/L VS 41.7 ± 4.5 [mu]mol/L, P < 0.05, at the second hour after oral Sr load) and urinay Pi excretion comparatively with animal controls. Plasma Sr levels remained very higher in treated animals than those measured in controls until the fifth hour of experimentation (52 ± 4.7 [mu]mol/L VS 42.1 ± 4.5 [mu]mol/L, P < 0.05). PTHrP did not induce significant variation on Ca or Sr renal excretion. Our results seem to show that PTHrP may play an important role on modulation of intestinal Ca absorption in camels.

Mots-clés Agrovoc : dromadaire, absorption digestive, calcium, peptide, hormone, parathyroïde, strontium, Camelus dromedarius

Classification Agris : L52 - Physiologie animale - Croissance et développement

Champ stratégique Cirad : Axe 1 (2005-2013) - Intensification écologique

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