Contagious bovine and caprine pleuropneumonia: a research community's recommendations for the development of better vaccines

Jores Joerg, Baldwin Cynthia, Blanchard Alain, Browning Glenn, Colston Angie, Gerdts Volker, Goovaerts Danny, Heller Martin, Juleff Nick, Labroussaa Fabien, Liljander Anne, Muuka Geoffrey, Nene Vish, Nir-Paz Ran, Sacchini Flavio, Summerfield Artur, Thiaucourt François, Unger Hermann, Vashee Sanjay, Salt Jeremy. 2021. Contagious bovine and caprine pleuropneumonia: a research community's recommendations for the development of better vaccines. In : XXIII Bienniel Congress of the International Organization for Mycoplasmology: Congress program. IOM. Tel Aviv : IOM, Résumé, 76-77. Bienniel Congress of the International Organization for Mycoplasmology (IOM 2021). 23, Tel Aviv, Israël, 1 Novembre 2021/4 Novembre 2021.

Note générale : Le congrès s'est tenu en ligne

Résumé : Background: Contagious bovine pleuropneumonia (CBPP) and contagious caprine pleuropneumonia (CCPP) are major infectious diseases of ruminants caused by mycoplasmas in Africa and Asia. Beyond their obvious impact on animal health, CBPP and CCPP negatively impact the livelihood and well being of a substantial proportion of livestock-dependent people affecting their culture, economy, trade and nutrition. The current vaccines used for disease control consist of a live attenuated CBPP vaccine and a bacter in vaccine for CCPP, which were developed in the 1960s and 1980s, respectively. Both of these vaccines have limitations, so better vaccines are urgently needed to improve control of these diseases. Methods: The research community met in 2018 for a workshop entitled 'Contagious bovine and caprine pleuropneumonia, an update on the current knowledge base', in Bern Switzerland. The exchange of information resulted in a number of prioritized biomedical research needs related to challenge models, vaccine target discovery and immune responses. Results: The outcome of this event highlighted the research gaps that will need to be overcome to develop safer and more effective vaccines for progressive disease control. This does not cover vaccine delivery, although we acknowledge that vaccine delivery is an important component of vaccine campaigns, especially in animals with a relatively low asset value. Conclusion: After rigorous scientific discussions, our suggested priority actions have been listed and should provide a frame for concerted action and funding. We believe these approaches will guide development of better vaccines that can be used as tools in the control of these two important pathogens.

Auteurs et affiliations

• Jores Joerg, University of Bern (CHE)
• Baldwin Cynthia, University of Massachusetts (USA)
• Blanchard Alain, INRAE (FRA)
• Browning Glenn, University of Melbourne (AUS)
• Colston Angie, GALVmed (GBR)
• Gerdts Volker, University of Saskatchewan (CAN)
• Goovaerts Danny, GALVmed (GBR)
• Heller Martin, FLI (DEU)
• Juleff Nick, Bill & Melinda Gates Foundation (USA)
• Labroussaa Fabien, University of Bern (CHE)
• Liljander Anne, ILRI (KEN)
• Muuka Geoffrey, Central Veterinary Research Institute (ZMB)
• Nene Vish, ILRI (KEN)
• Nir-Paz Ran, Hadassah-Hebrew University Medical Center (ISR)
• Sacchini Flavio, IZSA&M (ITA)
• Summerfield Artur, University of Bern (CHE)
• Thiaucourt François, CIRAD-BIOS-UMR ASTRE (FRA)
• Unger Hermann, FAO (AUT)
• Vashee Sanjay, JCVI (USA)
• Salt Jeremy, GALVmed (GBR)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/599618/)

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